男性乳腺癌——对曼彻斯特克里斯蒂医院及霍尔特镭研究所301例病例的回顾。
Male breast carcinoma--a review of 301 cases from the Christie Hospital & Holt Radium Institute, Manchester.
作者信息
Ribeiro G
出版信息
Br J Cancer. 1985 Jan;51(1):115-9. doi: 10.1038/bjc.1985.16.
Abstract
A series of 301 cases of male breast carcinoma has been analysed; of these, 292 have been treated at The Christie Hospital, Manchester and followed-up for a maximum of 15 years. The mean age was 63 years. The corrected survival was 52%, 38% and 36% at 5, 10 and 15 years respectively. For clinical Stage I, the 15 year survival was 61%. Since 1976, adjuvant Tamoxifen for one year has been administered to patients with operable Stage II (path) and Stage III disease following surgery and radiotherapy. Twenty-three patients so treated have a corrected survival of 55% at 5 years compared to 28% previously. Of 22 tumours assayed for oestrogen and progesterone receptors, 86% showed a positive result. For recurrent/metastatic disease, the drug Tamoxifen is recommended as the treatment of choice.
摘要
对301例男性乳腺癌病例进行了分析；其中，292例在曼彻斯特的克里斯蒂医院接受治疗，并进行了最长15年的随访。平均年龄为63岁。5年、10年和15年的校正生存率分别为52%、38%和36%。临床I期的15年生存率为61%。自1976年以来，对于可手术的II期（病理）和III期疾病患者，术后和放疗后给予辅助他莫昔芬治疗一年。接受如此治疗的23例患者5年校正生存率为55%，而之前为28%。在检测雌激素和孕激素受体的22个肿瘤中，86%呈阳性结果。对于复发/转移性疾病，推荐他莫昔芬作为首选治疗药物。
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