Fukumoto S, Matsumoto T, Harada S, Fujisaki J, Kawano M, Ogata E
Fourth Department of Internal Medicine, University of Tokyo School of Medicine, Japan.
J Clin Endocrinol Metab. 1991 Oct;73(4):877-81. doi: 10.1210/jcem-73-4-877.
Pheochromocytoma can cause several paraneoplastic syndromes. We report a patient with pheochromocytoma who exhibited pyrexia and marked inflammatory signs along with an elevated serum interleukin-6 (IL-6) level. All of these abnormalities disappeared and serum IL-6 became undetectable by removal of the tumor. In addition, immunohistochemical analysis revealed the presence of IL-6 in the tumor cells. It is suggested that pyrexia and the elevation of acute phase proteins can be a paraneoplastic syndrome with pheochromocytoma, and that the elaboration of IL-6 from pheochromocytoma may play an important role in the development of the syndrome.
嗜铬细胞瘤可引起多种副肿瘤综合征。我们报告了一例嗜铬细胞瘤患者，该患者出现发热、明显的炎症体征以及血清白细胞介素-6（IL-6）水平升高。切除肿瘤后，所有这些异常情况均消失，血清IL-6检测不到。此外，免疫组织化学分析显示肿瘤细胞中存在IL-6。提示发热和急性期蛋白升高可能是嗜铬细胞瘤的一种副肿瘤综合征，并且嗜铬细胞瘤分泌IL-6可能在该综合征的发生发展中起重要作用。
