11,12-断前列腺素。2. N-酰基-N-烷基-7-氨基庚酸。

11,12-Secoprostaglandins. 2. N-acyl-N-alkyl-7-aminoheptanoic acids.

作者信息

Jones J H, Holtz W J, Bicking J B, Cragoe E J, Mandel L R, Kuehl F A

出版信息

J Med Chem. 1977 Jan;20(1):44-8. doi: 10.1021/jm00211a008.

Abstract

A series of N-acyl-N-alkyl-7-aminoheptanoic acids has been prepared and evaluated for their ability to mimic the natural prostaglandins in certain biological systems. These compounds can be regarded as 8-aza-11,12-secoprostaglandins and, indeed, most of them stimulate cAMP formation in the mouse ovary assay, just as is observed with the natural prostaglandins. Selected compounds from this series also have been studied and shown to have prostaglandin-like effects in vivo.

摘要

已制备了一系列N-酰基-N-烷基-7-氨基庚酸，并对它们在某些生物系统中模拟天然前列腺素的能力进行了评估。这些化合物可被视为8-氮杂-11,12-断前列腺素，实际上，它们中的大多数在小鼠卵巢试验中能刺激环磷酸腺苷（cAMP）的形成，这与天然前列腺素的情况相同。该系列中的选定化合物也已进行研究，并显示在体内具有类前列腺素的作用。