11,12-断前列腺素。4. 7-（N-烷基甲磺酰胺基）庚酸。
11,12-secoprostaglandins. 4. 7-(N-alkylmethanesulfonamido) heptanoic acids.
作者信息
Jones J H, Holtz W J, Bicking J B, Cragoe E J
出版信息
J Med Chem. 1977 Oct;20(10):1299-304. doi: 10.1021/jm00220a014.
PMID:198546
Abstract
A series of 7-(N-alkylmethanesulfonamido) heptanoic acids has been prepared which represents an extension of our 8-aza-11,12-secoprostaglandin studies. The studies. The compounds mimic the natural prostaglandins in that they markedly stimulate cAMP formation in the mouse ovary assay.
摘要
已制备了一系列7-(N-烷基甲磺酰胺基)庚酸，这是我们对8-氮杂-11,12-断前列腺素研究的扩展。这些化合物在小鼠卵巢试验中能显著刺激环磷酸腺苷（cAMP）的形成，从而模拟天然前列腺素。
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