Gornati R, Rapelli S, Montorfano G, Cattaneo C, Berra B
Institute of General Physiology and Biological Chemistry, School of Pharmacy, University of Milano, Italy.
Int J Biol Markers. 1991 Apr-Jun;6(2):91-8. doi: 10.1177/172460089100600202.
In this paper a method is presented which is suitable for the extraction, purification and analysis of serum gangliosides. The advantage in comparison with other previously published procedures is the complete extraction of sialoglycolipids without contamination of sialoglycoproteins and/or sialoglycopeptides. The method could be used as a second-level test for the diagnosis and follow-up of cancer patients, and also could be potentially used for pharmaco-kinetic studies after ganglioside treatment.
本文介绍了一种适用于血清神经节苷脂提取、纯化及分析的方法。与其他先前发表的方法相比，其优点在于能完全提取唾液糖脂，且不会污染唾液糖蛋白和/或唾液糖肽。该方法可作为癌症患者诊断和随访的二级检测手段，也有可能用于神经节苷脂治疗后的药代动力学研究。
