Hogeweg M, Faber W R
Department of Ophthalmology, Erasmus University Rotterdam, The Netherlands.
Int J Lepr Other Mycobact Dis. 1991 Sep;59(3):392-7.
Forty-eight leprosy patients in The Netherlands were re-examined 10 years after initial examination. Forty-six of these patients had received a course of multidrug therapy (MDT), according to the World Health Organization recommendation, at the time of their initial examination. Two patients had burned-out disease and had been merely under observation. Out of 40 patients, who initially did not show eye complications due to leprosy, 37 patients were essentially the same 10 years later. The eyes had changed in 3 multibacillary patients: 1 patient had developed a late type 1 reaction with facial nerve involvement and lagophthalmos; 2 patients had undergone intra-ocular surgery for cataract and acute glaucoma, respectively. Out of 8 patients with pre-existing eye involvement, 1 patient recovered and the lesions in 2 patients remained unaltered. One patient showed progression of pre-existing exposure keratitis. Four patients had undergone cataract extractions; all four patients were lepromatous, with a long history of disease and signs of iris involvement at the first examination. The main progressive lesions were cataracts in lepromatous patients.
荷兰的48名麻风病患者在初次检查10年后接受了复查。其中46名患者在初次检查时已按照世界卫生组织的建议接受了多药联合治疗（MDT）疗程。2名患者病情已无活动，仅接受观察。在最初未表现出麻风病眼部并发症的40名患者中，37名患者在10年后基本情况相同。3名多菌型患者的眼睛出现了变化：1名患者发生了伴有面神经受累和兔眼的迟发型1型反应；2名患者分别接受了白内障和急性青光眼的眼内手术。在8名既往有眼部受累的患者中，1名患者康复，2名患者的病变保持不变。1名患者先前存在的暴露性角膜炎病情进展。4名患者接受了白内障摘除手术；所有4名患者均为瘤型麻风，病程长，初次检查时有虹膜受累迹象。主要的进行性病变是瘤型麻风患者的白内障。
