Rode J, Dhillon A P, Papadaki L, Griffiths D
Histopathology. 1982 Jan;6(1):69-79. doi: 10.1111/j.1365-2559.1982.tb02703.x.
Carcinoid tumours of the appendix are generally thought to be derived from enterochromaffin cells; in-situ abnormalities of these cells are, however, rarely observed in the mucosal epithelium. One hundred appendices, removed consecutively at surgery, were stained with an alcian blue-PAS diastase-lead haematoxylin sequence and, in 69, cells were found in the lamina propria with a cellular and architectural morphology identical to those of an archetypal appendiceal carcinoid tumour. These cells appeared to contain neurosecretory granules, were diazo-positive and showed argentaffinity. They were further characterized by the localization of cytoplasmic neurone specific enolase and the presence of neurosecretory granules was confirmed by electron microscopy. These cells are designated subepithelial neurosecretory cells (SNC). It is suggested they are an integral component of the subepithelial nervous plexus and are in progenitors of appendiceal carcinoid tumours. A neuroectodermal origin of the SNC-and hence appendiceal carcinoid tumours-is proposed.
阑尾类癌肿瘤一般被认为起源于肠嗜铬细胞；然而，这些细胞的原位异常在黏膜上皮中很少见到。对手术中连续切除的100个阑尾进行阿利新蓝-过碘酸雪夫氏反应-淀粉酶-铅苏木精染色序列处理，在69个阑尾的固有层中发现了细胞，其细胞和结构形态与典型的阑尾类癌肿瘤相同。这些细胞似乎含有神经分泌颗粒，重氮反应呈阳性且显示亲银性。它们进一步通过细胞质神经元特异性烯醇化酶的定位来表征，并且通过电子显微镜证实了神经分泌颗粒的存在。这些细胞被命名为上皮下神经分泌细胞（SNC）。有人提出它们是上皮下神经丛的一个组成部分，并且是阑尾类癌肿瘤的前体细胞。有人提出SNC以及因此阑尾类癌肿瘤起源于神经外胚层。
