单纯疱疹病毒复制周期中的光动力治疗
Photodynamic treatment of herpes simplex virus during its replicative cycle.
作者信息
Khan N C, Melnick J L, Biswal N
出版信息
J Virol. 1977 Jan;21(1):16-23. doi: 10.1128/JVI.21.1.16-23.1977.
Abstract
Photodynamic treatment of herpes simplex virus type 1-infected hamster embryo fibroblasts (LSH strain) with a low concentration of proflavine (0.08 mug/10(5) cells per ml), a 3-9-diamine acridine dye, inhibited production not only of infectious progeny but also of virion particles. However, there was no appreciable inhibition of viral or cellular DNA synthesis, even when the infected cells were repeatedly exposed to this low concentration of dye and light during the replication cycle of the virus. It thus appears that photodynamic treatment of infected cells interferes with the processes involved in virus maturation.
摘要
用低浓度的原黄素（每毫升0.08微克/10⁵个细胞），一种3,9 - 二氨基吖啶染料，对感染单纯疱疹病毒1型的仓鼠胚胎成纤维细胞（LSH株）进行光动力处理，不仅抑制了感染性子代的产生，还抑制了病毒粒子的产生。然而，即使在病毒复制周期中，将感染细胞反复暴露于这种低浓度的染料和光下，病毒或细胞DNA的合成也没有受到明显抑制。因此，对感染细胞进行光动力处理似乎会干扰病毒成熟过程。
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