2型单纯疱疹病毒对小鼠细胞的生化转化：通过低水平光动力治疗增强
Biochemical transformation of mouse cells by herpes simplex virus type 2: enhancement by means of low-level photodynamic treatment.
作者信息
Verwoerd D W, Rapp F
出版信息
J Virol. 1978 Apr;26(1):200-2. doi: 10.1128/JVI.26.1.200-202.1978.
Abstract
The biochemical transformation of thymidine kinase-deficient cells by UV-inactivated herpes simplex virus is enhanced by low-level photodynamic treatment of the infected cells. At the concentration of proflavine used, the virus was not inactivated and both virus and cellular DNA syntheses were only marginally inhibited. The observed enhancement of the transfer of a virus gene to the cell genome suggests a possible cocarcinogenic role for photodynamically active dyes at very low concentrations.
摘要
用紫外线灭活的单纯疱疹病毒对胸苷激酶缺陷细胞进行生化转化时，对受感染细胞进行低水平光动力处理可增强这种转化。在所使用的原黄素浓度下，病毒未被灭活，病毒和细胞DNA合成仅受到轻微抑制。观察到的病毒基因向细胞基因组转移的增强表明，极低浓度的光动力活性染料可能具有协同致癌作用。
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