可手术切除的结直肠癌的DNA倍体模式：100例前瞻性研究

Patterns of DNA-ploidy in operable colorectal carcinoma: a prospective study of 100 cases.

作者信息

Russo A, Bazan V, Plaja S, Leonardi P, Bazan P

机构信息

Centro Interdipartimentale di Richerche in Oncologia Clinica, University of Palermo, Italy.

出版信息

J Surg Oncol. 1991 Sep;48(1):4-10. doi: 10.1002/jso.2930480103.

DOI:10.1002/jso.2930480103

PMID:1890838

Abstract

A prospective study of cellular DNA content was made by means of flow cytometry in a nonconsecutive series of 100 patients undergoing surgery for primary colorectal adenocarcinoma. DNA-aneuploidy was present in 80% of cases (80/100); 39% of these were multiclonal (31/80). There was no significant correlation between DNA-ploidy and the clinical and pathological features examined, except for the primary tumor site (right colon vs. left colon vs. rectum: P less than 0.001). After a minimum follow-up of 30 months, out of 40 patients with no local invasion and/or distant metastases, 100% (9/9) of those with DNA-diploid neoplasias showed no signs of disease relapse, vs. 55% (17/31) of the DNA-aneuploid cases (P less than 0.05). Furthermore, in 45 cases with a minimum follow-up of 30 months, overall survival was 90% in patients with DNA-diploid carcinomas and 43% in the DNA-aneuploid cases (P less than 0.05).

摘要

采用流式细胞术对100例接受原发性大肠腺癌手术的非连续病例进行细胞DNA含量的前瞻性研究。80%（80/100）的病例存在DNA非整倍体；其中39%（31/80）为多克隆性。除原发肿瘤部位（右半结肠与左半结肠与直肠：P<0.001）外，DNA倍体与所检查的临床和病理特征之间无显著相关性。在至少随访30个月后，40例无局部侵犯和/或远处转移的患者中，DNA二倍体肿瘤患者100%（9/9）无疾病复发迹象，而DNA非整倍体病例为55%（17/31）（P<0.05）。此外，在45例至少随访30个月的病例中，DNA二倍体癌患者的总生存率为90%，DNA非整倍体病例为43%（P<0.05）。