Kovács G L, Bohus B, Versteeg D H, de Kloet E R, de Wied D
Brain Res. 1979 Oct 19;175(2):303-14. doi: 10.1016/0006-8993(79)91009-6.
The effects of local postlearning microinjections of arginine-vasopressin (AVP) and oxytocin (OXT) on one-trial learning passive avoidance behavior and the influence of AVP on alpha-MPT-induced disappearance of norepinephrine (NE) and dopamine (DA) in discrete brain regions have been studied in the rat. OXT injected bilaterally in the hippocampal dentate gyrus (25-25 pg) or in the midbrain dorsal raphe nucleus (50 pg) significantly attenuated passive avoidance behavior. Facilitation of passive avoidance behavior was observed when the peptide was injected into the dorsal septal nucleus. AVP facilitated passive avoidance behavior when administered into the hippocampal dentate gyrus, dorsal raphe nucleus or dorsal septal nucleus. Injection of either neuropeptides into the central amygdaloid nucleus appeared to be ineffective. One week after the behavioral experiments a repeated injection of AVP into the hippocampal dentate gyrus increased the disappearance of NE in the dentate gyrus and in the nucleus ruber. An injection into the dorsal septal nuclei decreased the NE disappearance in the dorsal septal nucleus itself and increased it in the nucleus ruber. Injection in the dorsal raphe nucleus led to an increase in the disappearance of DA in the locus coeruleus and in the nucleus ruber. It is concluded that memory consolidation can be oppositely influenced by local application of minute amounts of either OXT or AVP into certain limbic-midbrain structures, suggesting an involvement of these brain regions in the memory effects of these peptides. Modulation of catecholamine turnover in specific brain areas after AVP administration may be related to this behavioral effect.
研究了在大鼠中，学习后局部微量注射精氨酸加压素（AVP）和催产素（OXT）对单次试验学习的被动回避行为的影响，以及AVP对α-甲基对硫磷诱导的离散脑区去甲肾上腺素（NE）和多巴胺（DA）消失的影响。双侧海马齿状回（25 - 25 pg）或中脑背缝核（50 pg）注射OXT可显著减弱被动回避行为。当将该肽注入背隔核时，观察到被动回避行为得到促进。将AVP注入海马齿状回、背缝核或背隔核时，可促进被动回避行为。将任何一种神经肽注入中央杏仁核似乎无效。行为实验一周后，再次向海马齿状回注射AVP会增加齿状回和红核中NE的消失。注入背隔核会减少背隔核自身中NE的消失，并增加红核中的NE消失。注入背缝核会导致蓝斑和红核中DA的消失增加。结论是，向某些边缘 - 中脑结构局部应用微量的OXT或AVP可对记忆巩固产生相反的影响，这表明这些脑区参与了这些肽的记忆效应。AVP给药后特定脑区儿茶酚胺代谢的调节可能与这种行为效应有关。
