el-Mofty M M, Khudoley V V, Shwaireb M H
Department of Zoology, Faculty of Science, University of Alexandria, Egypt.
Oncology. 1991;48(4):347-50. doi: 10.1159/000226955.
50 male and 50 female Bufo regularis were treated, by force-feeding, with an extract of black pepper, at a dose level of 2 mg, 3 times a week for 5 months. The first tumors appeared after 2 months. Liver tumors (hepatocellular carcinomas, lymphosarcomas and fibrosarcomas) were found in 12 males and 18 females. Metastatic deposits of hepatocellular carcinomas were registered in the spleen, kidney, fat body and ovary.
对50只雄性和50只雌性普通蟾蜍进行强制喂食，给予黑胡椒提取物，剂量为2毫克，每周3次，持续5个月。2个月后出现首批肿瘤。在12只雄性和18只雌性蟾蜍中发现了肝脏肿瘤（肝细胞癌、淋巴肉瘤和纤维肉瘤）。在脾脏、肾脏、脂肪体和卵巢中发现了肝细胞癌的转移灶。
