Sadek I A
Oncology. 1981;38(1):23-6. doi: 10.1159/000225515.
Neoplasms of the liver were induced in 18 cases out of 44 in the Egyptian toad, Bufo regularis, by injection with 20-methylcholanthrene. Dose level was 10 mg/50 g body weight once a week. However, the injection of the same dose level of this hydrocarbon together with vitamin A palmitate on the level of 20,000 IU/50 g body weight once a week was found to develop hepatomas in the liver in only 1 of 45 cases. Results of this study indicate that vitamin A palmitate inhibited the carcinogenic effect of 20-methylcholanthrene.
通过向44只埃及蟾蜍（Bufo regularis）中的18只注射20-甲基胆蒽诱导出肝脏肿瘤。剂量水平为每周每50克体重注射10毫克。然而，发现每周一次以每50克体重20000国际单位的剂量水平将该碳氢化合物与棕榈酸视黄酯一起注射时，45只蟾蜍中只有1只在肝脏中发生了肝癌。这项研究的结果表明，棕榈酸视黄酯抑制了20-甲基胆蒽的致癌作用。
