Wolner B, Liebmann J M, Sassani J W, Ritch R, Speaker M, Marmor M
Department of Ophthalmology, New York Eye and Ear Infirmary, New York City 10003.
Ophthalmology. 1991 Jul;98(7):1053-60. doi: 10.1016/s0161-6420(91)32177-8.
The incidence of late-onset bleb-related endophthalmitis was evaluated retrospectively in 229 consecutive trabeculectomies performed with adjunctive 5-fluorouracil (5-FU) therapy. Mean follow-up was 23.7 +/- 16.3 months (range, 3 to 60 months). Thirteen eyes (5.7%) of 11 patients developed bleb-related endophthalmitis an average of 25.9 +/- 17.4 months (range, 5 to 58 months) after surgery. Infection occurred in 9 of 96 (9.4%) procedures performed from below and in 4 of 133 (3.0%) procedures performed superiorly (P = 0.05, Fisher's exact test). The relative risk of bleb-related endophthalmitis in trabeculectomy from below versus above is 4.0 after adjustment for age and sex (95% confidence interval = 1.1, 14.8). Trabeculectomy with adjunctive 5-FU performed from below carries an increased risk of late bleb-related infection. The incidence of late bleb-related endophthalmitis after 5-FU trabeculectomy appears to be higher than that for trabeculectomy without adjunctive 5-FU injections.
对连续229例采用辅助性5-氟尿嘧啶（5-FU）治疗的小梁切除术患者的迟发性滤过泡相关眼内炎发病率进行了回顾性评估。平均随访时间为23.7±16.3个月（范围3至60个月）。11例患者的13只眼（5.7%）在手术后平均25.9±17.4个月（范围5至58个月）发生了滤过泡相关眼内炎。下方进行的96例手术中有9例（9.4%）发生感染，上方进行的133例手术中有4例（3.0%）发生感染（P=0.05，Fisher精确检验）。在对年龄和性别进行调整后，下方小梁切除术与上方小梁切除术相比，滤过泡相关眼内炎的相对风险为4.0（95%置信区间=1.1,14.8）。下方进行的辅助性5-FU小梁切除术发生迟发性滤过泡相关感染的风险增加。5-FU小梁切除术后迟发性滤过泡相关眼内炎的发病率似乎高于未进行辅助性5-FU注射的小梁切除术。
