Hashimoto M, Yanaki T, Nakahara N, Masuzawa T
Department of Surgical Neurology, Jichi Medical School, Tochigi-ken, Japan.
Surg Neurol. 1991 Aug;36(2):137-44. doi: 10.1016/0090-3019(91)90232-x.
Lymphocytic adenohypophysitis is a rare inflammatory disorder of the anterior pituitary gland. In some cases, there is evidence of concurrent autoimmune disease. We present the case of a 39-year-old woman who developed visual disturbance during the early postpartum period. Magnetic resonance imaging revealed an intrasellar mass with suprasellar extension. Study of the tumor tissue showed diffuse infiltration of the entire pituitary gland by lymphocytes and plasma cells. Immunohistochemical examination revealed that the majority of the infiltrating lymphocytes were T cells that might have modulated the immunoreaction to the anterior pituitary gland. We suggest that the disorder is related to cell-mediated immunity as well as humoral immunity.
淋巴细胞性垂体前叶炎是一种罕见的垂体前叶炎症性疾病。在某些病例中，有并发自身免疫性疾病的证据。我们报告一例39岁女性，在产后早期出现视觉障碍。磁共振成像显示鞍内肿块并向上延伸至鞍上。肿瘤组织研究显示整个垂体被淋巴细胞和浆细胞弥漫性浸润。免疫组织化学检查显示，大多数浸润淋巴细胞为T细胞，可能调节了对垂体前叶的免疫反应。我们认为该疾病与细胞介导免疫以及体液免疫均有关。
