[Immunologic disorders in patients with primary hypothyroidism].

Most patients with primary hypothyroidism showed changes in the immune status manifested in a reduction of the number and functional activity of T-lymphocytes, increased sensibilization of lymphoid cells to thyreoglobulin, content of B-lymphocytes, serum immunoglobulins of M, G classes, antithyreoglobin antibody titer and circulating immune complexes. The frequency and grade of immune disorders are directly related to the severity of the disease. The most pronounced changes were revealed in spontaneous hypothyroidism.