Hong Seok Min, Byun Jae Yong, Park Chan Hum, Lee Jun Ho, Park Moon Suh, Cha Chang Il
Department of Otorhinolaryngology-Head and Neck Surgery, Chuncheon Sacred Heart Hospital, Hallym University College of Medicine, Chuncheon, Korea.
Otolaryngol Head Neck Surg. 2008 Oct;139(4):541-5. doi: 10.1016/j.otohns.2008.07.003.
Saccule could be damaged in patients with idiopathic sudden sensorineural hearing loss (ISSHL) with vertigo and with high-frequency sensorineural hearing loss. Thus, the saccule might be deteriorated subclinically in ISSHL cases without vertigo. Therefore, we investigated saccular damage in ISSHL patients without vertigo through vestibular evoked myogenic potentials (VEMP).
A prospective study.
Fifty-two patients with ISSHL without vertigo were enrolled in the study. We identified VEMP in patients with ISSHL and analyzed the association of VEMP with initial hearing threshold, each threshold according to frequency, the type of audiogram, and hearing recovery.
For cases with absent VEMP, we found significant differences between patients with 90 dB or more hearing loss and those with a hearing loss less than 55 dB with frequencies over 1000 Hz. Patients with profound hearing loss presented significantly high abnormal and absent VEMP than patients with audiograms of other types.
These findings suggest that the subclinical deterioration of the saccular neuroepithelium is associated with patients with ISSHL having profound hearing loss at the high frequency.
在伴有眩晕和高频感音神经性听力损失的特发性突发性感音神经性听力损失（ISSHL）患者中，球囊可能会受损。因此，在无眩晕的ISSHL病例中，球囊可能会发生亚临床退变。因此，我们通过前庭诱发肌源性电位（VEMP）研究了无眩晕的ISSHL患者的球囊损伤情况。
一项前瞻性研究。
52例无眩晕的ISSHL患者纳入本研究。我们对ISSHL患者进行了VEMP检测，并分析了VEMP与初始听力阈值、各频率阈值、听力图类型及听力恢复情况之间的关联。
对于VEMP缺失的病例，我们发现听力损失90dB或更高的患者与听力损失小于55dB且频率超过1000Hz的患者之间存在显著差异。重度听力损失患者的VEMP异常和缺失情况明显高于其他类型听力图的患者。
这些发现表明，球囊神经上皮的亚临床退变与高频重度听力损失的ISSHL患者有关。
