Baxter G M, Parks A H, Prasse K W
Department of Large Animal Medicine, College of Veterinary Medicine, University of Georgia, Athens 30602.
Am J Vet Res. 1991 Jul;52(7):1121-7.
Plasma and peritoneal fluid samples were collected before and after surgery from 6 horses undergoing a ventral midline exploratory laparotomy and from 6 anesthetized control horses. Coagulation/fibrinolytic components measured in the plasma and peritoneal fluid of these horses included the functional activity of antithrombin III, alpha-2 antiplasmin, plasminogen, and protein C, and the concentrations of fibrinogen and fibrin degradation products. Peritoneal fluid antithrombin III, fibrin degradation products, and plasminogen values were significantly increased after surgery (over time) in principal horses. Compared with control horses, postoperative peritoneal fluid from horses undergoing laparotomy had significantly increased antithrombin-III activity at 12 and 72 hours, alpha-2 antiplasmin activity at 24 hours, fibrin degradation product concentrations at 6, 12, 24, 72, 96, and 144 hours, plasminogen activity at 6, 12, 24, 48, 72 and 96 hours, and protein-C activity at 12, 24, 72, and 96 hours. There were no significant changes in the peritoneal fibrinogen concentration in principal horses. Plasma plasminogen activity was significantly decreased at 24 hours after surgery in principal horses, compared with controls. Changes were minimal in the remaining plasma coagulation/fibrinolytic components of horses undergoing laparotomy. Plasma and peritoneal fluid values of anesthetized control horses did not change.
从6匹接受腹中线剖腹探查术的马以及6匹麻醉的对照马身上，在手术前后采集血浆和腹腔液样本。在这些马的血浆和腹腔液中检测的凝血/纤维蛋白溶解成分包括抗凝血酶III、α-2抗纤溶酶、纤溶酶原和蛋白C的功能活性，以及纤维蛋白原和纤维蛋白降解产物的浓度。主要马匹术后（随时间推移）腹腔液中的抗凝血酶III、纤维蛋白降解产物和纤溶酶原值显著增加。与对照马相比，接受剖腹术的马术后腹腔液在12小时和72小时时抗凝血酶III活性显著增加，24小时时α-2抗纤溶酶活性增加，6小时、12小时、24小时、72小时、96小时和144小时时纤维蛋白降解产物浓度增加，6小时、12小时、24小时、48小时、72小时和96小时时纤溶酶原活性增加，12小时、24小时、72小时和96小时时蛋白C活性增加。主要马匹腹腔纤维蛋白原浓度无显著变化。与对照相比，主要马匹术后24小时血浆纤溶酶原活性显著降低。接受剖腹术的马其余血浆凝血/纤维蛋白溶解成分变化最小。麻醉对照马的血浆和腹腔液值未发生变化。
