Papamichael D, Audisio R, Horiot J-C, Glimelius B, Sastre J, Mitry E, Van Cutsem E, Gosney M, Köhne C-H, Aapro M
Department of Medical Oncology, B.O. C. Oncology Centre, Nicosia, Cyprus.
Ann Oncol. 2009 Jan;20(1):5-16. doi: 10.1093/annonc/mdn532. Epub 2008 Oct 15.
Colorectal cancer (CRC) is one of the commonest malignancies of Western countries, with approximately half the incidence occurring in patients >70 years of age. Elderly CRC patients, however, are understaged, undertreated and underrepresented in clinical trials. The International Society of Geriatric Oncology created a task force with a view to assessing the potential for developing guidelines for the treatment of elderly (geriatric) CRC patients. A review of the evidence presented by the task force members confirmed the paucity of clinical trial data in elderly people and the lack of evidence-based guidelines. However, recommendations have been proposed on the basis of the available data and on the emerging evidence that treatment outcomes for fit, elderly CRC patients can be similar to those of younger patients. It is hoped that these will pave the way for formal treatment guidelines based upon solid scientific evidence in the future.
结直肠癌（CRC）是西方国家最常见的恶性肿瘤之一，约一半的病例发生在70岁以上的患者中。然而，老年CRC患者在临床试验中的分期不足、治疗不足且代表性不足。国际老年肿瘤学会成立了一个特别工作组，旨在评估制定老年（老年）CRC患者治疗指南的可能性。对特别工作组成员提供的证据进行审查后发现，老年人的临床试验数据匮乏，且缺乏循证指南。不过，已根据现有数据和新出现的证据提出了建议，即健康的老年CRC患者的治疗结果可能与年轻患者相似。希望这些建议能为未来基于确凿科学证据的正式治疗指南铺平道路。
