Department of Medical Oncology, B.O. Cyprus Oncology Centre, Nicosia, Cyprus
St Helens Teaching Hospital, St Helens, UK.
Ann Oncol. 2015 Mar;26(3):463-76. doi: 10.1093/annonc/mdu253. Epub 2014 Jul 11.
Colorectal cancer (CRC) is one of the most commonly diagnosed cancers in Europe and worldwide, with the peak incidence in patients >70 years of age. However, as the treatment algorithms for the treatment of patients with CRC become ever more complex, it is clear that a significant percentage of older CRC patients (>70 years) are being less than optimally treated. This document provides a summary of an International Society of Geriatric Oncology (SIOG) task force meeting convened in Paris in 2013 to update the existing expert recommendations for the treatment of older (geriatric) CRC patients published in 2009 and includes overviews of the recent data on epidemiology, geriatric assessment as it relates to surgery and oncology, and the ability of older CRC patients to tolerate surgery, adjuvant chemotherapy, treatment of their metastatic disease including palliative chemotherapy with and without the use of the biologics, and finally the use of adjuvant and palliative radiotherapy in the treatment of older rectal cancer patients. An overview of each area was presented by one of the task force experts and comments invited from other task force members.
结直肠癌（CRC）是欧洲和全球最常见的癌症之一，发病率峰值出现在>70 岁的患者中。然而，随着 CRC 患者治疗方案的日益复杂，很明显，相当一部分老年 CRC 患者（>70 岁）的治疗效果并不理想。本文件总结了 2013 年在巴黎召开的国际老年肿瘤学会（SIOG）工作组会议，该会议旨在更新 2009 年发布的关于老年（老年）CRC 患者治疗的现有专家建议，并概述了最近关于流行病学、与手术和肿瘤学相关的老年综合评估、以及老年 CRC 患者对手术、辅助化疗、转移性疾病治疗（包括使用和不使用生物制剂的姑息化疗）的耐受性，以及辅助和姑息性放疗在治疗老年直肠癌患者中的应用。工作组的一位专家介绍了每个领域的概述，并邀请其他工作组成员发表评论。
