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一名血清中存在EBV和HPV(-16及-33型)的HIV患者发生鼻咽鳞状细胞癌的致命快速进展

Fatal fast-evolution of nasopharyngeal squamous cell carcinoma in an HIV patient with EBV and HPV (-16 AND -33) in blood serum.

作者信息

Sirera Guillem, Videla Sebastià, Romeu Joan, Cañadas Maripaz, Fernández Maria-Teresa, Balo Susana, Cirauqui Beatriz, Darwich Laila, Rey-Joly Celestino, Clotet Bonaventura

机构信息

HIV Clinical Unit, Department of Medicine, Lluita Contra La SIDA Foundation, Spain.

出版信息

Open AIDS J. 2008;2:1-2. doi: 10.2174/1874613600802010001. Epub 2008 Feb 6.

DOI:10.2174/1874613600802010001
PMID:18923693
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2556196/
Abstract

Our case illustrates the first report of an HIV-infected patient with a nasopharyngeal squamous cell carcinoma with viremia by one Epstein-Barr virus (EBV) and seropositivity by two high risk oncogenic human papilloma viruses (HPV)-types (HPV-16 and HPV-33), previous to his death. This patient presented a fatal fast-evolution.

摘要

我们的病例首次报告了一名艾滋病毒感染患者,在其死亡前患有鼻咽鳞状细胞癌,伴有由一种爱泼斯坦-巴尔病毒(EBV)引起的病毒血症以及两种高危致癌性人乳头瘤病毒(HPV)类型(HPV-16和HPV-33)的血清阳性。该患者病情呈致命性快速进展。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b627/2556196/1dae69c75037/TOAIDJ-2-1_F1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b627/2556196/1dae69c75037/TOAIDJ-2-1_F1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b627/2556196/1dae69c75037/TOAIDJ-2-1_F1.jpg

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本文引用的文献

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Human papillomavirus in cervical and head-and-neck cancer.宫颈癌和头颈癌中的人乳头瘤病毒
Nat Clin Pract Oncol. 2008 Jan;5(1):24-31. doi: 10.1038/ncponc0984.
2
Clinical implications of human papillomavirus in head and neck cancers.人乳头瘤病毒在头颈癌中的临床意义。
J Clin Oncol. 2006 Jun 10;24(17):2606-11. doi: 10.1200/JCO.2006.06.1291.
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The expression of functional chemokine receptor CXCR4 is associated with the metastatic potential of human nasopharyngeal carcinoma.功能性趋化因子受体CXCR4的表达与人类鼻咽癌的转移潜能相关。
Clin Cancer Res. 2005 Jul 1;11(13):4658-65. doi: 10.1158/1078-0432.CCR-04-1798.
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Serum/plasma viral DNA: mechanisms and diagnostic applications to nasopharyngeal and cervical carcinoma.血清/血浆病毒DNA:鼻咽癌和宫颈癌的机制及诊断应用
Ann N Y Acad Sci. 2001 Sep;945:59-67.
5
Detection and quantitation of human papillomavirus (HPV) DNA in the sera of patients with HPV-associated head and neck squamous cell carcinoma.人乳头瘤病毒(HPV)相关头颈部鳞状细胞癌患者血清中人乳头瘤病毒(HPV)DNA的检测与定量分析
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6
Evidence for a causal association between human papillomavirus and a subset of head and neck cancers.人乳头瘤病毒与一部分头颈癌之间存在因果关联的证据。
J Natl Cancer Inst. 2000 May 3;92(9):709-20. doi: 10.1093/jnci/92.9.709.