Tatlı Doğan Hayriye, Kılıçarslan Aydan, Doğan Mehmet, Süngü Nuran, Güler Tezel Gaye, Güler Gülnur
Ankara Atatürk Education and Research Hospital, Department of Pathology, Üniversiteler Mahallesi Bilkent Caddesi No: 1, 06800, Çankaya, Ankara, Turkey.
Yıldırım Beyazıt University, Ankara Atatürk Education and Research Hospital, Department of Pathology, Üniversiteler Mahallesi Bilkent Caddesi No: 1, 06800, Çankaya, Ankara, Turkey.
Pathol Res Pract. 2016 Nov;212(11):1021-1026. doi: 10.1016/j.prp.2016.08.013. Epub 2016 Sep 3.
Nasopharyngeal carcinoma (NPC) is associated with the Epstein-Barr virus (EBV). Human papilloma virus (HPV) has also been detected in NPC cases. In this retrospective study, we analyze the frequency of EBV and HPV infection in 82 Turkish patients with NPC. A total of 82 were evaluated for EBV and HPV. In situ hybridization (ISH) was performed for EBV. HPV-ISH and P16 immunohistochemistry used to determine the HPV status. Seventy-two of the 82 (87%) NPC patients were EBV-positive. The highest rate of EBV-positivity was found in undifferentiated NPC patients, which accounted for 65 of 68 (95.6%) undifferentiated cases. One of the 82 NPC patients whose tumor was non-keratinizing differentiated, contained HPV. Our data shows that EBV is closely associated with NPC in Turkey. We found lower rates of HPV-positivity in NPC patients than in North American populations. In addition, both EBV and HPV-negativity were more associated with decreased survival than EBV-positive cases.
鼻咽癌（NPC）与爱泼斯坦-巴尔病毒（EBV）有关。在鼻咽癌病例中也检测到了人乳头瘤病毒（HPV）。在这项回顾性研究中，我们分析了82例土耳其鼻咽癌患者中EBV和HPV感染的频率。共有82例患者接受了EBV和HPV评估。对EBV进行了原位杂交（ISH）检测。HPV-ISH和P16免疫组化用于确定HPV状态。82例鼻咽癌患者中有72例（87%）EBV呈阳性。EBV阳性率最高的是未分化鼻咽癌患者，68例未分化病例中有65例（95.6%）呈阳性。82例肿瘤为非角化分化型的鼻咽癌患者中有1例含有HPV。我们的数据表明，在土耳其，EBV与鼻咽癌密切相关。我们发现鼻咽癌患者的HPV阳性率低于北美人群。此外，与EBV阳性病例相比，EBV和HPV均为阴性与生存率降低的相关性更大。
