Montanaro L, Campoccia D, Arciola C R
Research Unit on Implant Infections, Rizzoli Orthopedic Institute, Bologna and Department of Experimental Pathology of the University of Bologna, Bologna - Italy.
Int J Artif Organs. 2008 Sep;31(9):771-6. doi: 10.1177/039139880803100904.
Orthopedic implants may fail owing to different reasons: poor osseointegration at the tissue-implant interface, generation of wear debris, stress and strain imbalance between implant and surrounding tissues, and infections. To ensure success in orthopedics, implant materials must not evoke an undesirable inflammatory response, they must be habitable by bone-forming cells (favoring adhesion of osteoblasts), hinder formation of soft connective tissue (hindering adhesion of fibroblasts), and be anti-infective (discouraging bacterial adhesion). Recent studies have suggested that nanophase materials have a better efficacy as bone implants in favoring osseointegration compared to conventional orthopedic implant materials. This minireview discusses studies on nanophase materials as bone implants, focusing on the effect of these materials in inhibiting bacterial adhesion for the prevention of implant infections.
组织-植入物界面处的骨整合不良、磨损碎屑的产生、植入物与周围组织之间的应力和应变失衡以及感染。为确保骨科手术成功，植入材料不得引发不良的炎症反应，必须适合骨形成细胞生长（有利于成骨细胞黏附），阻碍软结缔组织形成（阻碍成纤维细胞黏附），并且具有抗感染能力（抑制细菌黏附）。最近的研究表明，与传统骨科植入材料相比，纳米相材料作为骨植入物在促进骨整合方面具有更好的效果。本综述讨论了关于纳米相材料作为骨植入物的研究，重点关注这些材料在抑制细菌黏附以预防植入物感染方面的作用。
