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[酒精性痴呆的临床概念]

[Clinical concept of alcoholic dementia].

作者信息

Kato N

机构信息

Psychiatric Research Institute of Tokyo.

出版信息

Arukoru Kenkyuto Yakubutsu Ison. 1991 Jun;26(3):119-33.

PMID:1892448
Abstract

Intellectual deterioration, changing in behavior and affect are often seen in association with long continued and heavy alcohol ingestion and such deteriorated states of patients are called alcoholic dementia. A large number of investigators have attempted to designate clinical concept of alcoholic dementia throughout the centuries and many kinds of term like as alcoholic pseudo-paralysis, alcoholic mental deficiency and alcoholic deterioration, etc, have been submitted since the beginning of 19th century. Numerous psychometric studies have indicated cognitive impairment and memory disturbance in chronic alcohol abusers and moreover brain PEG and CT-scan studies have shown sulcal widening and enlarged ventricles to be common in alcoholics. However, alcoholic dementia is hard to classify as a distinct disorder caused by alcoholic ingestion. The reason is lack of specific findings, both clinical and histopathological, like as Wernicke-Korsakoff syndrome and other nutritional disorders in alcoholics. Victor, M. describes in his work the majority of patients who have come to autopsy with the clinical diagnosis of primary alcoholic dementia have shown the lesions of the Wernicke-Korsakoff syndrome and he postulates alcoholic dementia is heavily contaminated with burned-out Wernicke-Korsakoff disease. The clinical and pathological observations presented by this time represent alcoholic dementia is a residual category for cases in which there are severe impairment of intelligence with marked deterioration of personality following prolonged and heavy drinking.

摘要

智力衰退、行为和情感变化常与长期大量饮酒有关,患者的这种衰退状态被称为酒精性痴呆。几个世纪以来,大量研究人员试图界定酒精性痴呆的临床概念,自19世纪初以来,人们提出了许多术语,如酒精性假性麻痹、酒精性智力缺陷和酒精性衰退等。大量心理测量学研究表明,慢性酗酒者存在认知障碍和记忆障碍,此外,脑部PEG和CT扫描研究显示,酗酒者脑沟增宽和脑室扩大很常见。然而,酒精性痴呆很难被归类为由饮酒引起的一种独特疾病。原因是缺乏像韦尼克-科尔萨科夫综合征及酗酒者的其他营养障碍那样的临床和组织病理学特异性表现。维克托·M.在其著作中描述,大多数临床诊断为原发性酒精性痴呆并已进行尸检的患者都表现出韦尼克-科尔萨科夫综合征的病变,他推测酒精性痴呆严重受已发展成终末期的韦尼克-科尔萨科夫病的影响。目前呈现的临床和病理观察结果表明,酒精性痴呆是长期大量饮酒后出现严重智力损害并伴有明显人格衰退的病例的一个残余类别。

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