基于胱抑素C清除率估算慢性肾脏病（CKD）患儿的肾小球滤过率

[Estimation of glomerular filtration rate in children with chronic kidney disease (CKD) on the basis of cystatin C clearance].

作者信息

Sekowska Renata, Roszkowska-Blaim Maria

机构信息

Katedra i Klinika Pediatrii i Nefrologii, Warszawski Uniwersytet Medyczny.

出版信息

Pol Merkur Lekarski. 2008;24 Suppl 4:61-4.

PMID:18924505

Abstract

UNLABELLED

Glomerular filtration rate (GFR) is the best marker of renal function. Creatinine and cystatin C are accepted as endogenous parameters of GFR.

THE AIM

Comparison between cystatin C clearance and other methods used for estimation of GFR.

MATERIAL AND METHODS

The study group consist of 73 children mean age 12.26 +/- 4.18, with CKD stage 1-4. We determined clearance of creatinine using Schwartz formule (Cl(Sch)), Counahan-Barratt formule (Cl(C-B)), cystatin C clearance (Cl(cystC)) and referred them for nuclear clearance investigations--technetium-diethylenetriamine pentaacetic acid (Cl(99m)Tc-DTPA).

RESULTS

Mean values of GFR (ml/min/1.73 m2) amounted to: Cl(Sch) 113.87 +/- 36.98; Cl(C-B) 84.74 +/- 29.73; Cl(cystC) 89.55 +/- 25.87; Cl(99m)Tc-DTPA 87.28 +/- 30.71. Significant correlations were found (p < 0.00001) between Cl(99m)Tc-DTPA and Cl(Sch) r = 0.72; Cl(C-B) r = 0.71 and Cl(cystC) r = 0.72. Receiver-operating characteristics analysis showed that there where no significant differences between these methods for estimation GFR.

CONCLUSION

Cystatin C clearance is an alternative method for determination of GFR.

摘要

未标注

肾小球滤过率（GFR）是肾功能的最佳指标。肌酐和胱抑素C被视为GFR的内源性参数。

目的

比较胱抑素C清除率与其他用于估算GFR的方法。

材料与方法

研究组由73名平均年龄为12.26±4.18岁的儿童组成，处于慢性肾脏病1 - 4期。我们使用施瓦茨公式（Cl(Sch)）、库纳汉 - 巴拉特公式（Cl(C - B)）测定肌酐清除率，胱抑素C清除率（Cl(cystC)），并让他们接受核素清除率检查——锝 - 二乙三胺五乙酸（Cl(99m)Tc - DTPA）。

结果

GFR（ml/min/1.73 m²）的平均值为：Cl(Sch) 113.87±36.98；Cl(C - B) 84.74±29.73；Cl(cystC) 89.55±25.87；Cl(99m)Tc - DTPA 87.28±30.71。发现Cl(99m)Tc - DTPA与Cl(Sch)之间存在显著相关性（p < 0.00001），r = 0.72；与Cl(C - B)，r = 0.71；与Cl(cystC)，r = 0.72。受试者工作特征分析表明，这些估算GFR的方法之间没有显著差异。