Chiu Kuan-Chi, Tsai Tsung-Chang, Lin Wei-Tung, Lee Wei-Jen, Su Ching-Chyuan, Chen Chen-Yin
Department of Radiology, Tinan Municipal Hospital, Tainan City, Taiwan, ROC.
Ren Fail. 2008;30(9):939-42. doi: 10.1080/08860220802353918.
A female concurrently developed polymyositis (PM), lung cancer, and nephrotic range proteinuria. Renal biopsy revealed crescentic glomerulonephritis. Pathology of lung cancer was proved to be adenocarcinoma. After surgical treatment of lung cancer, the symptoms of PM-associated crescentic glomerulonephritis disappeared. PM is associated with a higher risk of malignancy, though renal involvement in patients with PM is thought to be uncommon. In patients with PM, there have been few reports concerning the coexistence of glomerular disease, including crescent glomerulonephritis. Herein we report a case of crescentic glomerulonephritis-associated PM that was successfully treated after the surgical removal of lung cancer. We consider that such association of PM and crescent glomerulonephritis is rare in adults. Careful evaluation of underlying malignancy is important. The definite treatment is adequate management of underlying malignancy.
一名女性同时患多发性肌炎（PM）、肺癌和肾病范围蛋白尿。肾活检显示新月体性肾小球肾炎。肺癌病理证实为腺癌。肺癌手术治疗后，PM相关新月体性肾小球肾炎症状消失。虽然PM患者的肾脏受累被认为不常见，但PM与恶性肿瘤风险较高相关。在PM患者中，关于包括新月体性肾小球肾炎在内的肾小球疾病共存的报道很少。在此，我们报告一例经手术切除肺癌后成功治疗的新月体性肾小球肾炎相关PM病例。我们认为这种PM与新月体性肾小球肾炎的关联在成年人中很少见。仔细评估潜在恶性肿瘤很重要。明确的治疗是对潜在恶性肿瘤进行充分管理。
