Wong Ching-Yuen, Qiuwaxi Jianati, Chen Hua, Li Sheung-Wai, Chan Hiu-Ting, Tam Sidney, Shu Xiao-Ou, Lau Chu-Pak, Kwong Yok-Lam, Tse Hung-Fat
Cardiology Division, Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong, China.
Mol Nutr Food Res. 2008 Dec;52(12):1421-7. doi: 10.1002/mnfr.200800056.
Our objective was to determine the relationships between levels of different dietary nutrients intake with circulating endothelial progenitor cells (EPC) and vascular endothelial function in type II diabetic patients. We studied the daily dietary nutrients intake, the numbers of circulating CD34(+)/KDR(+) EPC and CD133(+)/KDR(+) EPC and brachial artery flow-mediated dilation (FMD) in 88 diabetic patients without prior cardiovascular diseases and 91 sex- and age-matched controls. Compared with controls, diabetic patients had lower CD133(+)/KDR(+) EPC count (48.3 +/- 5.2 vs. 84.6 +/- 7.6/microL, p < 0.001), CD34(+)/KDR(+) EPC count (311 +/- 41 vs. 412 +/- 36/microL, p = 0.045), and FMD (2.54 +/- 0.37% vs. 5.46 +/- 0.47%, p < 0.001). After adjusted for age, sex, smoking history, body weight, hemoglobin A1c level, total calorie intake, other dietary vitamin intake, use of antihypertensives, and lipid lowering agents, a higher intake of thiamine was significantly associated with a higher level of circulating CD34(+)/KDR(+) EPC (beta = 0.49, p = 0.028) and CD133(+)/KDR(+) EPC (beta = 0.45, p = 0.037) in diabetic patients, but not in controls. Furthermore, an increased intake of thiamine from 1st to 4th quartile in diabetic patients independently predicted an absolute increase in FMD by 1.29% (p = 0.026, relative increase = 63.5%). This study demonstrated that daily thiamine intake was positively correlated with the circulating number of EPCs and FMD in patients with type II diabetes, independent of other dietary nutrients intake.
我们的目标是确定II型糖尿病患者不同膳食营养素摄入量与循环内皮祖细胞（EPC）水平及血管内皮功能之间的关系。我们研究了88例无心血管疾病史的糖尿病患者以及91例年龄和性别匹配的对照者的每日膳食营养素摄入量、循环CD34(+)/KDR(+) EPC和CD133(+)/KDR(+) EPC数量以及肱动脉血流介导的血管舒张功能（FMD）。与对照组相比，糖尿病患者的CD133(+)/KDR(+) EPC计数较低（48.3±5.2对84.6±7.6/μL，p<0.001），CD34(+)/KDR(+) EPC计数较低（311±41对412±36/μL，p = 0.045），FMD较低（2.54±0.37%对5.46±0.47%，p<0.001）。在校正年龄、性别、吸烟史、体重、糖化血红蛋白水平、总热量摄入、其他膳食维生素摄入、抗高血压药物使用和降脂药物使用后，硫胺素摄入量较高与糖尿病患者循环CD34(+)/KDR(+) EPC水平较高（β = 0.49，p = 0.028）和CD133(+)/KDR(+) EPC水平较高（β = 0.45，p = 0.037）显著相关，但在对照组中无此关联。此外，糖尿病患者硫胺素摄入量从第一四分位数增加到第四四分位数可独立预测FMD绝对增加1.29%（p = 0.026，相对增加 = 63.5%）。本研究表明，II型糖尿病患者的每日硫胺素摄入量与EPC循环数量及FMD呈正相关，且独立于其他膳食营养素摄入量。
