Division of Cardiology, Department of Medicine, Queen Mary Hospital, the University of Hong Kong, Hong Kong, China.
BMC Cardiovasc Disord. 2014 Feb 21;14:24. doi: 10.1186/1471-2261-14-24.
Previous studies suggested that high dietary carbohydrate intake is associated with increased cardiovascular risk through raised triglyceride and decreased high-density lipoprotein-cholesterol levels. However, the relation between carbohydrate intake and arterial stiffness has not been established. The purpose of this study was to examine this relation among high-risk cardiovascular patients.
We studied the relation between dietary macronutrient intake and arterial stiffness in 364 patients with documented cardiovascular diseases or risk equivalent (coronary artery diseases 62%, ischemic stroke 13%, diabetes mellitus 55%) and in 93 age-and-sex matched control subjects. Dietary macronutrient intake was assessed using a validated food-frequency questionnaire (FFQ) for Chinese. Heart-ankle pulse wave velocity (PWV) was measured non-invasively with a Vascular Profiling System (VP2000, Colin Corp. USA). A dietary pattern with ≥60% total energy intake derived from carbohydrates was defined as a high-carbohydrate diet according to the Dietary Reference Intakes (DRI) for Chinese.
Subjects who consumed a high-carbohydrate diet had significantly higher mean PWV than those who did not consume a high-carbohydrate diet (P = 0.039). After adjustment for potential confounders, high-carbohydrate diet was associated with significantly increased PWV [B = 73.50 (10.81 to 136.19), P = 0.022]. However, there was no significant association between high-carbohydrate diet and PWV in controls (P = 0.634).
High-carbohydrate diet is associated with increased arterial stiffness in patients with established cardiovascular disease or risk equivalent.
先前的研究表明，高碳水化合物饮食通过升高甘油三酯和降低高密度脂蛋白胆固醇水平与增加心血管风险有关。然而，碳水化合物摄入量与动脉僵硬之间的关系尚未确定。本研究的目的是在高危心血管患者中研究这种关系。
我们研究了 364 例有记录的心血管疾病或风险等同（冠心病 62%，缺血性脑卒中 13%，糖尿病 55%）和 93 名年龄和性别匹配的对照者的饮食宏量营养素摄入与动脉僵硬之间的关系。使用经过验证的中文食物频率问卷（FFQ）评估饮食宏量营养素摄入。使用血管轮廓分析系统（VP2000，美国科林公司）无创测量心踝脉搏波速度（PWV）。根据中国膳食参考摄入量（DRI），将总能量摄入的≥60%来自碳水化合物的饮食模式定义为高碳水化合物饮食。
与不食用高碳水化合物饮食的受试者相比，食用高碳水化合物饮食的受试者的平均 PWV 显著更高（P = 0.039）。在调整潜在混杂因素后，高碳水化合物饮食与 PWV 显著增加相关[B = 73.50（10.81 至 136.19），P = 0.022]。然而，在对照组中，高碳水化合物饮食与 PWV 之间没有显著关联（P = 0.634）。
高碳水化合物饮食与已确诊的心血管疾病或风险等同患者的动脉僵硬增加有关。
