DNA methylation: its role in cancer development and therapy.
作者信息
Kurkjian Carla, Kummar Shivaani, Murgo Anthony J
机构信息
Advanced Developmental Therapeutics Training Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute, Bethesda, Maryland, USA.
出版信息
Curr Probl Cancer. 2008 Sep-Oct;32(5):187-235. doi: 10.1016/j.currproblcancer.2008.08.002.
Abstract
摘要
相似文献
1
DNA methylation: its role in cancer development and therapy.DNA甲基化：其在癌症发展和治疗中的作用。
Curr Probl Cancer. 2008 Sep-Oct;32(5):187-235. doi: 10.1016/j.currproblcancer.2008.08.002.
2
DNA methylation inhibitors in the treatment of leukemias, myelodysplastic syndromes and hemoglobinopathies: clinical results and possible mechanisms of action.DNA甲基化抑制剂在白血病、骨髓增生异常综合征和血红蛋白病治疗中的临床结果及可能的作用机制
Curr Top Microbiol Immunol. 2000;249:135-64. doi: 10.1007/978-3-642-59696-4_9.
3
Targeting DNA methylation.靶向DNA甲基化
Clin Cancer Res. 2009 Jun 15;15(12):3938-46. doi: 10.1158/1078-0432.CCR-08-2783. Epub 2009 Jun 9.
4
Decitabine effect on tumor global DNA methylation and other parameters in a phase I trial in refractory solid tumors and lymphomas.地西他滨对难治性实体瘤和淋巴瘤I期试验中肿瘤整体DNA甲基化及其他参数的影响。
Clin Cancer Res. 2009 Jun 1;15(11):3881-8. doi: 10.1158/1078-0432.CCR-08-2196. Epub 2009 May 26.
5
Decitabine and its role in the treatment of hematopoietic malignancies.地西他滨及其在造血系统恶性肿瘤治疗中的作用。
Leuk Lymphoma. 2007 Aug;48(8):1472-81. doi: 10.1080/10428190701471981.
6
Myelodysplasia, megakaryocytes, and methylation.骨髓发育异常、巨核细胞与甲基化
Leuk Res. 2004 Aug;28(8):775-6. doi: 10.1016/j.leukres.2004.01.003.
7
Evaluation of a 7-day continuous intravenous infusion of decitabine: inhibition of promoter-specific and global genomic DNA methylation.7天持续静脉输注地西他滨的评估：对启动子特异性和全基因组DNA甲基化的抑制作用
J Clin Oncol. 2005 Jun 10;23(17):3897-905. doi: 10.1200/JCO.2005.06.118. Epub 2005 Mar 7.
8
Decitabine.地西他滨
Recent Results Cancer Res. 2010;184:131-57. doi: 10.1007/978-3-642-01222-8_10.
9
Will DNA methylation inhibitors work in solid tumors? A review of the clinical experience with azacitidine and decitabine in solid tumors.DNA 甲基化抑制剂在实体瘤中有效吗？阿扎胞苷和地西他滨在实体瘤中临床应用经验的综述。
Epigenomics. 2010 Feb;2(1):71-86. doi: 10.2217/epi.09.44.
10
Decitabine is an effective treatment of idiopathic myelofibrosis.地西他滨是治疗原发性骨髓纤维化的一种有效疗法。
Br J Haematol. 2009 Apr;145(1):131-2. doi: 10.1111/j.1365-2141.2008.07541.x. Epub 2008 Dec 26.
引用本文的文献
1
Differential DNA Methylation of the Brain-Derived Neurotrophic Factor Gene is Observed after Pediatric Traumatic Brain Injury Compared to Orthopedic Injury.与骨科损伤相比，小儿创伤性脑损伤后观察到脑源性神经营养因子基因的差异DNA甲基化。
medRxiv. 2025 Jun 16:2025.06.16.25329571. doi: 10.1101/2025.06.16.25329571.
2
The Distribution and Predictive Factor of Extra-Pancreatic Malignancy Occurrence in Patients with Pancreatic Intraductal Papillary Mucinous Neoplasm-A Ten-Year Follow-Up Case-Control Study in Taiwan.胰腺导管内乳头状黏液性肿瘤患者胰外恶性肿瘤发生的分布及预测因素——台湾一项十年随访病例对照研究
Cancers (Basel). 2024 Dec 7;16(23):4102. doi: 10.3390/cancers16234102.
3
Brain-Derived Neurotrophic Factor in Pediatric Acquired Brain Injury and Recovery.脑源性神经营养因子在儿科获得性脑损伤及康复中的作用
Biomolecules. 2024 Feb 4;14(2):191. doi: 10.3390/biom14020191.
4
Insight into the Epigenetics of Kaposi's Sarcoma-Associated Herpesvirus.卡波氏肉瘤相关疱疹病毒表观遗传学研究进展。
Int J Mol Sci. 2023 Oct 6;24(19):14955. doi: 10.3390/ijms241914955.
5
DNA methylation drives a new path in gastric cancer early detection: Current impact and prospects.DNA甲基化在胃癌早期检测中开辟新路径：当前影响与前景
Genes Dis. 2023 Mar 30;11(2):847-860. doi: 10.1016/j.gendis.2023.02.038. eCollection 2024 Mar.
6
Integrative bioinformatics and RNA sequencing based methodology results in the exploration of breast invasive carcinoma biomarkers.基于整合生物信息学和RNA测序的方法有助于探索乳腺浸润性癌生物标志物。
Am J Transl Res. 2023 May 15;15(5):3067-3091. eCollection 2023.
7
Histone Demethylase Modulation: Epigenetic Strategy to Combat Cancer Progression.组蛋白去甲基化酶调控：对抗癌症进展的表观遗传策略。
Epigenomes. 2023 May 17;7(2):10. doi: 10.3390/epigenomes7020010.
8
Circulating Tumor DNA Methylation Biomarkers for Characterization and Determination of the Cancer Origin in Malignant Liver Tumors.用于表征和确定恶性肝肿瘤癌症起源的循环肿瘤DNA甲基化生物标志物
Cancers (Basel). 2023 Jan 30;15(3):859. doi: 10.3390/cancers15030859.
9
Molecular basis of epigenetic regulation in cancer diagnosis and treatment.癌症诊断与治疗中表观遗传调控的分子基础。
Front Genet. 2022 Aug 24;13:885635. doi: 10.3389/fgene.2022.885635. eCollection 2022.
10
Epigenetic Regulation of Inflammatory Signaling and Inflammation-Induced Cancer.炎症信号的表观遗传调控与炎症诱导的癌症
Front Cell Dev Biol. 2022 Jun 8;10:931493. doi: 10.3389/fcell.2022.931493. eCollection 2022.
本文引用的文献
1
A phase I trial of two sequence-specific schedules of decitabine and vorinostat in patients with acute myeloid leukemia.一项针对急性髓性白血病患者的地西他滨和伏立诺他两种序列特异性给药方案的I期试验。
Leuk Lymphoma. 2015;56(10):2793-802. doi: 10.3109/10428194.2015.1018248. Epub 2015 Mar 30.
2
Long-term epigenetic therapy with oral zebularine has minimal side effects and prevents intestinal tumors in mice.长期口服泽布替尼进行表观遗传治疗副作用极小，并可预防小鼠肠道肿瘤。
Cancer Prev Res (Phila). 2008 Sep;1(4):233-40. doi: 10.1158/1940-6207.CAPR-07-0008. Epub 2008 Mar 19.
3
DLEC1 and MLH1 promoter methylation are associated with poor prognosis in non-small cell lung carcinoma.DLEC1和MLH1启动子甲基化与非小细胞肺癌的不良预后相关。
Br J Cancer. 2008 Jul 22;99(2):375-82. doi: 10.1038/sj.bjc.6604452. Epub 2008 Jul 1.
4
Concurrent methylation of promoters from tumor associated genes predicts outcome in acute myeloid leukemia.肿瘤相关基因启动子的同时甲基化可预测急性髓系白血病的预后。
Leuk Lymphoma. 2008 Jun;49(6):1132-41. doi: 10.1080/10428190802035990.
5
Molecular analysis of nipple fluid for breast cancer screening.用于乳腺癌筛查的乳头溢液分子分析。
Pathobiology. 2008;75(2):149-52. doi: 10.1159/000123853. Epub 2008 Jun 10.
6
Epigenetic inactivation of secreted Frizzled-related proteins in acute myeloid leukaemia.分泌型卷曲相关蛋白在急性髓系白血病中的表观遗传失活
Br J Haematol. 2008 Sep;142(5):745-53. doi: 10.1111/j.1365-2141.2008.07242.x. Epub 2008 Jun 3.
7
Aberrant CpG island methylation in acute myeloid leukemia is accentuated at relapse.急性髓系白血病中异常的CpG岛甲基化在复发时会加剧。
Blood. 2008 Aug 15;112(4):1366-73. doi: 10.1182/blood-2007-11-126227. Epub 2008 Jun 3.
8
Promoter methylation-associated loss of ID4 expression is a marker of tumour recurrence in human breast cancer.启动子甲基化相关的ID4表达缺失是人类乳腺癌肿瘤复发的一个标志物。
BMC Cancer. 2008 May 30;8:154. doi: 10.1186/1471-2407-8-154.
9
2'-Deoxy-N4-[2-(4-nitrophenyl)ethoxycarbonyl]-5-azacytidine: a novel inhibitor of DNA methyltransferase that requires activation by human carboxylesterase 1.2'-脱氧-N4-[2-(4-硝基苯基)乙氧基羰基]-5-氮杂胞苷：一种新型DNA甲基转移酶抑制剂，需经人羧酸酯酶1激活。
Cancer Lett. 2008 Aug 8;266(2):238-48. doi: 10.1016/j.canlet.2008.02.069. Epub 2008 May 21.
10
CpG hypermethylation of the UCHL1 gene promoter is associated with pathogenesis and poor prognosis in renal cell carcinoma.UCHL1基因启动子的CpG高甲基化与肾细胞癌的发病机制及不良预后相关。
J Urol. 2008 Jul;180(1):343-51. doi: 10.1016/j.juro.2008.02.044. Epub 2008 May 21.
Zotero 插件