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出生后前三个月内的重症先天性主动脉瓣狭窄手术。

Surgery for critical congenital aortic stenosis during the first three months of life.

作者信息

Messmer B J, Hofstetter R, von Bernuth G

机构信息

Department of Thoracic and Cardiovascular Surgery, Clinics of RWTH, Aachen, FRG.

出版信息

Eur J Cardiothorac Surg. 1991;5(7):378-82. doi: 10.1016/1010-7940(91)90056-p.

DOI:10.1016/1010-7940(91)90056-p
PMID:1892668
Abstract

Open commissurotomy for critical aortic stenosis has been performed in a consecutive series of 28 neonates and infants below 3 months of age (average age 1 month) including 5 patients with severe organic mitral valve disease in need of concomitant correction. In the majority of cases, aortic stenosis was due not only to fused commissures but also to excessive immature valve tissue protruding into the valve area. Therefore a technique of extended commissurotomy has been adopted resecting such nodules responsible for a secondary level stenosis. All operations were done under deep hypothermia (17 degrees C), circulatory arrest (33 +/- 11 min) and cardioplegia using the Bretschneider solution (35-50 ml/kg). Hospital mortality was 18% (5) including 1 infant dying at 2 months of thrombosed mitral prosthesis inserted at a secondary operation. Severe organic mitral valve disease proved to be the only significant risk factor for early mortality. During the follow-up period of up to 10 years (average 5 years), 1 child with a hypoplastic left heart died and 2 children had to undergo reoperation for residual and recurrent stenosis, respectively. Actuarial survival for the present series is 78% at 10 years while reoperation free survival for the aortic valve is 64%. It is concluded that careful and if necessary extended open commissurotomy still represents the method of choice in this age group. Alternative methods such as transventricular or percutaneous dilatation did not show a lower risk until now and long-term results are not convincing as yet.

摘要

对连续28例3个月以下(平均年龄1个月)的新生儿和婴儿实施了治疗严重主动脉瓣狭窄的直视交界切开术,其中5例患有严重器质性二尖瓣疾病,需要同期矫治。在大多数病例中,主动脉瓣狭窄不仅是由于瓣叶交界融合,还因为有过多未成熟的瓣膜组织突入瓣膜区。因此,采用了一种扩大交界切开术,切除导致继发性狭窄的结节。所有手术均在深低温(17℃)、循环停止(33±11分钟)以及使用布雷施奈德溶液(35 - 50毫升/千克)进行心脏停搏的情况下进行。住院死亡率为18%(5例),其中1例婴儿在二次手术植入二尖瓣人工瓣膜后2个月死于血栓形成。严重器质性二尖瓣疾病被证明是早期死亡的唯一重要危险因素。在长达10年(平均5年)的随访期内,1例左心发育不全的患儿死亡,2例患儿分别因残余和复发性狭窄而不得不再次手术。本系列的10年实际生存率为78%,而主动脉瓣无再次手术生存率为64%。结论是,仔细且必要时扩大的直视交界切开术仍是该年龄组的首选方法。诸如经心室或经皮扩张等替代方法目前并未显示出更低的风险,且长期结果也尚不令人信服。

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