中枢神经系统生殖细胞瘤：最佳治疗策略是什么？

CNS germinomas: what is the best treatment strategy?

作者信息

Hadziahmetovic Mersiha, Clarke James W, Cavaliere Robert, Mayr Nina A, Montebello Joseph F, Grecula John C, Newton Herbert B, Chang Eric L, Lo Simon S

机构信息

Department of Radiation Oncology, The University of Texas Medical Branch, Trauma Center, 301 University Boulevard, Galveston, TX 77555-1178, USA.

出版信息

Expert Rev Neurother. 2008 Oct;8(10):1527-36. doi: 10.1586/14737175.8.10.1527.

DOI:10.1586/14737175.8.10.1527

PMID:18928345

Abstract

CNS germ cell tumors are rare primary brain malignancies. Germinomas comprise approximately two-thirds of CNS germ cell tumors. Owing to their radiosensitivity, radiotherapy has been used to treat patients with CNS germinomas, with favorable treatment outcomes. Historically, craniospinal irradiation has been used. Given the concerns over long-term toxicities associated with craniospinal irradiation, reduced volume radiotherapy with or without chemotherapy has been employed. Data on the use of different strategies in the treatment of CNS germinomas are emerging but a standard strategy has not been established. This article reviews the different strategies used in the management of CNS germinomas.

摘要

中枢神经系统生殖细胞肿瘤是罕见的原发性脑恶性肿瘤。生殖细胞瘤约占中枢神经系统生殖细胞肿瘤的三分之二。由于其放射敏感性，放射治疗已被用于治疗中枢神经系统生殖细胞瘤患者，治疗效果良好。历史上，曾采用全脑全脊髓照射。鉴于对全脑全脊髓照射相关长期毒性的担忧，已采用减少照射体积的放疗联合或不联合化疗。关于在中枢神经系统生殖细胞瘤治疗中使用不同策略的数据正在不断涌现，但尚未确立标准策略。本文综述了中枢神经系统生殖细胞瘤管理中使用的不同策略。