母亲的中和抗体与丙型肝炎病毒向婴儿的传播
Maternal neutralizing antibody and transmission of hepatitis C virus to infants.
作者信息
Dowd Kimberly A, Hershow Ronald C, Yawetz Sigal, Larussa Philip, Diaz Clemente, Landesman Sheldon H, Paul Mary E, Read Jennifer S, Lu Ming, Thomas David L, Netski Dale M, Ray Stuart C
机构信息
Department of Medicine, Johns Hopkins Medical Institutions, Johns Hopkins University School of Medicine, 855 N. Wolfe Street, Baltimore, MD 21205, USA.
出版信息
J Infect Dis. 2008 Dec 1;198(11):1651-5. doi: 10.1086/593067.
Abstract
To determine whether lower levels of hepatitis C virus (HCV)-specific neutralizing antibodies (nAb) are associated with an increased risk of mother-to-child transmission (MTCT) of HCV, HCV nAb titers were assessed in 63 mothers coinfected with HCV and human immunodeficiency virus (HIV) type 1. Of the mothers, 16 transmitted HCV to their infant, but no difference was detected between the ability of maternal plasma from transmitters and nontransmitters to neutralize heterologous HCV pseudoparticles (median nAb titer, 1:125 vs. 1:100; P = .23). In the setting of HIV/HCV coinfection, we found no evidence that HCV nAbs are associated with the prevention of MTCT of HCV.
摘要
为了确定较低水平的丙型肝炎病毒（HCV）特异性中和抗体（nAb）是否与HCV母婴传播（MTCT）风险增加相关，我们对63例同时感染HCV和1型人类免疫缺陷病毒（HIV）的母亲进行了HCV nAb滴度评估。这些母亲中，有16例将HCV传播给了她们的婴儿，但在传播者和非传播者的母体血浆中和异源HCV假病毒颗粒的能力之间未检测到差异（中位nAb滴度，1:125对1:100；P = 0.23）。在HIV/HCV合并感染的情况下，我们没有发现证据表明HCV nAb与预防HCV的MTCT有关。
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2
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J Infect Dis. 2007 Mar 15;195(6):857-63. doi: 10.1086/511826. Epub 2007 Feb 7.
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Gastroenterology. 2007 Feb;132(2):667-78. doi: 10.1053/j.gastro.2006.12.008. Epub 2006 Dec 3.
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6
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