前瞻性随访研究丙型肝炎病毒母婴垂直感染儿童的中和抗体。
Neutralizing antibodies to hepatitis C virus in perinatally infected children followed up prospectively.
机构信息
Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.
出版信息
J Infect Dis. 2011 Dec 1;204(11):1741-5. doi: 10.1093/infdis/jir631. Epub 2011 Oct 17.
Abstract
Little is known about the presence and role of neutralizing antibodies (NtAbs) in perinatal hepatitis C virus (HCV) infection. Using HCV pseudoparticles, NtAbs were studied longitudinally in 12 HCV-infected children with or without evidence of acute hepatitis during the first year of life. Broadly reactive NtAbs of maternal origin did not prevent vertical HCV transmission or progression to chronicity. NtAbs against homologous genotype or subtype appeared during the chronic phase and were more abundant and sustained in children with acute hepatitis. Cross-reactive NtAbs were present in both groups of children, but their appearance did not correlate with better control of viremia or HCV clearance.
摘要
关于中和抗体（NtAbs）在围产期丙型肝炎病毒（HCV）感染中的存在和作用知之甚少。本研究使用 HCV 假病毒，对 12 例 HCV 感染儿童进行了纵向研究，这些儿童在生命的第一年有或无急性肝炎的证据。母体来源的广泛反应性 NtAbs 并不能预防垂直 HCV 传播或进展为慢性感染。针对同源基因型或亚型的 NtAbs 在慢性期出现，并且在有急性肝炎的儿童中更为丰富和持续。交叉反应性 NtAbs 存在于两组儿童中，但它们的出现与更好地控制病毒血症或 HCV 清除无关。
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