丙型肝炎病毒在人类免疫缺陷病毒1型感染母亲中的围产期传播。妇女与婴儿传播研究。
Perinatal transmission of hepatitis C virus from human immunodeficiency virus type 1-infected mothers. Women and Infants Transmission Study.
作者信息
Thomas D L, Villano S A, Riester K A, Hershow R, Mofenson L M, Landesman S H, Hollinger F B, Davenny K, Riley L, Diaz C, Tang H B, Quinn T C
机构信息
Division of Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.
出版信息
J Infect Dis. 1998 Jun;177(6):1480-8. doi: 10.1086/515315.
Antepartum plasma hepatitis C virus (HCV) RNA was quantified in 155 mothers coinfected with HCV and human immunodeficiency virus type 1 (HIV-1), and HCV RNA was serially assessed in their infants. Of 155 singleton infants born to HCV antibody-positive mothers, 13 (8.4%) were HCV infected. The risk of HCV infection was 3.2-fold greater in HIV-1-infected infants compared with HIV-1-uninfected infants (17.1% of 41 vs. 5.4% of 112, P = .04). The median concentration of plasma HCV RNA was higher among the 13 mothers with HCV-infected infants (2.0 x 10(6) copies/mL) than among the 142 mothers with HCV-negative infants (3.5 x 10(5) copies/mL; P < .001), and there were no instances of HCV transmission from 40 mothers with HCV RNA concentrations of < 10(5) copies/mL. Women dually infected with HIV-1 and HCV but with little or no detectable HCV RNA should be reassured that the risk of perinatal transmission of HCV is exceedingly low.
对155名同时感染丙型肝炎病毒（HCV）和1型人类免疫缺陷病毒（HIV-1）的母亲进行了产前血浆HCV RNA定量检测，并对她们的婴儿进行了HCV RNA的系列评估。在HCV抗体阳性母亲所生的155名单胎婴儿中，13名（8.4%）感染了HCV。与未感染HIV-1的婴儿相比，感染HIV-1的婴儿感染HCV的风险高3.2倍（41名中的17.1%对112名中的5.4%，P = 0.04）。13名婴儿感染HCV的母亲血浆HCV RNA的中位数浓度（2.0×10⁶拷贝/毫升）高于142名婴儿未感染HCV的母亲（3.5×10⁵拷贝/毫升；P < 0.001），并且40名HCV RNA浓度<10⁵拷贝/毫升的母亲没有出现HCV传播的情况。同时感染HIV-1和HCV但几乎检测不到或检测不到HCV RNA的女性应放心，HCV围产期传播的风险极低。
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