诺米芬辛的中枢作用。
Central action of nomifensine.
作者信息
Maj J, Kapturkiewicz Z, Michaluk J
出版信息
Pol J Pharmacol Pharm. 1976 Nov-Dec;28(6):557-62.
PMID:189291
Abstract
Nomifensine, a new antidepressant drug, affects the central noradrenergic neurons in the rat. Nomifensine does not affect the noradrenaline level in the brain, but retards the depletion of noradrenaline after inhibition of its synthesis. Apomorphine and dimethylaminoadamantane accelerate the depletion of noradrenaline and amphetamine does not affect it. Nomifensine potentiates the flexor reflex of the hind paw of a spinal rat and depresses the body temperature.
摘要
诺米芬辛是一种新型抗抑郁药物，它会影响大鼠中枢去甲肾上腺素能神经元。诺米芬辛不影响大脑中的去甲肾上腺素水平，但在抑制其合成后可延缓去甲肾上腺素的耗竭。阿扑吗啡和二甲氨基金刚烷会加速去甲肾上腺素的耗竭，而苯丙胺则对其无影响。诺米芬辛可增强脊髓大鼠后爪的屈肌反射并降低体温。
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