mTOR信号传导：RAG GTP酶传递氨基酸信号。
mTOR signaling: RAG GTPases transmit the amino acid signal.
作者信息
Shaw Reuben J
机构信息
Molecular and Cell Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA.
出版信息
Trends Biochem Sci. 2008 Dec;33(12):565-8. doi: 10.1016/j.tibs.2008.09.005. Epub 2008 Oct 15.
Abstract
mTOR (mammalian target of rapamycin) is a highly conserved nutrient-responsive regulator of cell growth that is found in all eukaryotes. The mechanism by which amino acids signal to mTOR has remained one of the largest outstanding questions in the field. Two recent complimentary studies provide compelling evidence that the Rag family of small GTPases is both necessary and sufficient to transmit a positive signal from amino acids to mTOR.
摘要
mTOR（哺乳动物雷帕霉素靶蛋白）是一种在所有真核生物中都存在的高度保守的细胞生长营养响应调节因子。氨基酸向mTOR发出信号的机制一直是该领域最大的悬而未决的问题之一。最近两项互补的研究提供了令人信服的证据，表明小GTP酶Rag家族对于将氨基酸的正向信号传递给mTOR既是必要的也是充分的。
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