Habiboallah Ghanbari, Nasroallah Saghravanian, Mahdi Zakery, Nasser Mahdavi Shahri, Massoud Zakery, Ehsan Baradaran Nasseri, Mina Zareian Jahromi, Heidar Parsaei
Department of Periodontics, School of Dentistry and Dental Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
J Ethnopharmacol. 2008 Dec 8;120(3):335-41. doi: 10.1016/j.jep.2008.09.011. Epub 2008 Sep 20.
The experimental finding of Asian traditional medicine revealed the pharmacological effect of the local application of ghee which was taken from cow butterfat and the rhizomes of Curcuma longa. These materials significantly improved the healing process of the wound. In addition, ancient physicians of Middle East discovered that the powdered rhizomes of Curcuma longa (common turmeric) also had impressive medicinal qualities. Over the centuries, this spice has been used as a pain relieving, anti-inflammatory agent to relieve pain and inflammation in the skin and muscles.
We decided to mix ghee which was taken from sheep butterfat with the powdered rhizomes of Curcuma longa to formulate a novel cost-benefit material and then, evaluate its potential therapeutic effect on acceleration of surgical wound healing; moreover, this present study was performed to compare the effects of Curcuma longa-ghee formulation and hyaluronic acid on gingival wound healing following surgery.
Five healthy 3-year-old male beagle dogs were used in this study. They had intact teeth and the clinical and radiographic examination revealed no periodontal disease. Ghee was obtained from the refined sheep butterfat heated to 70 degrees C mixed with the powdered rhizomes of Curcuma longa and was applied with two different ratios including materials A and B. Randomly, these three materials including hyaluronic acid, materials A and B were applied topically in test regions and then covered with periodontal pack. Histological changes were monitored in days 4 and 7 after operation to evaluate the inflammatory and repair stage of healing process.
We observed significant difference in the inflammatory and repair parameters of the healing process between cases treated with this new formulation and cases of hyaluronic acid application.
The results suggested a positive potential therapeutic effect on surgical wound healing particularly improvement of periodontal treatment consequences after surgery.
亚洲传统医学的实验发现揭示了源自牛乳脂肪和姜黄根茎的酥油局部应用的药理作用。这些材料显著改善了伤口的愈合过程。此外，中东的古代医生发现姜黄（普通姜黄）的根茎粉末也具有令人印象深刻的药用特性。几个世纪以来，这种香料一直被用作止痛、抗炎剂，以缓解皮肤和肌肉的疼痛和炎症。
我们决定将源自羊乳脂肪的酥油与姜黄根茎粉末混合，以配制一种新型的性价比高的材料，然后评估其对加速手术伤口愈合的潜在治疗效果；此外，本研究还比较了姜黄 - 酥油配方和透明质酸对术后牙龈伤口愈合的影响。
本研究使用了5只健康的3岁雄性比格犬。它们牙齿完好，临床和影像学检查未发现牙周疾病。酥油由加热至70摄氏度的精制羊乳脂肪与姜黄根茎粉末混合而成，并以两种不同比例应用，包括材料A和材料B。随机地，将透明质酸、材料A和材料B这三种材料局部应用于测试区域，然后用牙周塞治剂覆盖。在术后第4天和第7天监测组织学变化，以评估愈合过程的炎症和修复阶段。
我们观察到用这种新配方治疗的病例与应用透明质酸的病例在愈合过程的炎症和修复参数方面存在显著差异。
结果表明对手术伤口愈合具有积极的潜在治疗效果，特别是改善了术后牙周治疗的效果。
