生物合成的银纳米颗粒调节腭部伤口模型中的炎症。
Biosynthesized Silver Nanoparticles Modulate Inflammation in a Palatine Wound Model.
作者信息
Guzzatti Morgana Francisco Machado, de Moura Airam Barbosa, Venturini Ligia Milanez, de Roch Casagrande Laura, Lima Igor Ramos, da Costa Camila, de Pieri Ellen, Tietbohl Lariani Tamires Witt, Feuser Paulo Emilio, Machado-de-Ávila Ricardo Andrez, Gu Yaodong, Thirupathi Anand, Silveira Paulo Cesar Lock
机构信息
Laboratory of Experimental Physiopathology, Program of postgraduate in Science of Health, Universidade do Extremo Sul Catarinense, Criciúma, Santa Catarina state, Brazil.
Department of Rehabilitation Medicine, Ningbo No. 2 Hospital, Ningbo, Zhejiang, China.
出版信息
Clin Exp Dent Res. 2025 Oct;11(5):e70213. doi: 10.1002/cre2.70213.
OBJECTIVES
This study aimed to compare the effects of silver nanoparticles (AgNPs) synthesized with Curcumin (Curcuma longa L.) or Açai (Euterpe oleracea) versus a commercial treatment and photobiomodulation in rat palatal wounds.
METHODS
In vitro cell viability tests assessed nanoparticle toxicity. The animals were initially anesthetized, and circular lesions were created in the palatine mucosa using a 4 mm/diameter punch. The first treatment session commenced 24 h after the injury and continued daily for 5 days. Twenty-four hours after the final treatment, the animals were euthanized, and the palatal mucosa tissue was collected for histological and biochemical analyses.
RESULTS
AgNPs-Cur significantly reduced pro-inflammatory cytokines and oxidant markers, increased anti-inflammatory cytokines, the wound contraction rate, and the collagen area, and reduced the inflammatory infiltrate compared to the controls.
CONCLUSION
The therapies effectively aided inflammation resolution and accelerated tissue repair. This study highlights potential cost-effective and efficient alternatives for oral and palatal mucosa wound healing, improving upon standard commercial treatments.
目的
本研究旨在比较用姜黄素（姜黄）或阿萨伊果（巴西莓）合成的银纳米颗粒与一种商业治疗方法及光生物调节对大鼠腭部伤口的影响。
方法
体外细胞活力测试评估纳米颗粒的毒性。动物首先麻醉，然后用直径4毫米的打孔器在腭黏膜上制造圆形损伤。首次治疗在受伤后24小时开始，持续5天，每天进行。最后一次治疗24小时后，对动物实施安乐死，并收集腭黏膜组织进行组织学和生化分析。
结果
与对照组相比，姜黄素合成的银纳米颗粒显著降低促炎细胞因子和氧化标志物，增加抗炎细胞因子、伤口收缩率和胶原面积，并减少炎症浸润。
结论
这些治疗方法有效促进炎症消退并加速组织修复。本研究突出了口腔和腭黏膜伤口愈合具有潜在成本效益且高效的替代方法，优于标准商业治疗。
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