Akbik Dania, Ghadiri Maliheh, Chrzanowski Wojciech, Rohanizadeh Ramin
Faculty of Pharmacy, The University of Sydney, Sydney, NSW 2006, Australia.
Faculty of Pharmacy, The University of Sydney, Sydney, NSW 2006, Australia; Department of Nanobiomedical Science & BK21 PLUS NBM Global Research Center for Regenerative Medicine, Dankook University, Cheonan 330-714, Republic of Korea.
Life Sci. 2014 Oct 22;116(1):1-7. doi: 10.1016/j.lfs.2014.08.016. Epub 2014 Sep 6.
Turmeric (Curcuma longa) is a popular Indian spice that has been used for centuries in herbal medicines for the treatment of a variety of ailments such as rheumatism, diabetic ulcers, anorexia, cough and sinusitis. Curcumin (diferuloylmethane) is the main curcuminoid present in turmeric and responsible for its yellow color. Curcumin has been shown to possess significant anti-inflammatory, anti-oxidant, anti-carcinogenic, anti-mutagenic, anti-coagulant and anti-infective effects. Curcumin has also been shown to have significant wound healing properties. It acts on various stages of the natural wound healing process to hasten healing. This review summarizes and discusses recently published papers on the effects of curcumin on skin wound healing. The highlighted studies in the review provide evidence of the ability of curcumin to reduce the body's natural response to cutaneous wounds such as inflammation and oxidation. The recent literature on the wound healing properties of curcumin also provides evidence for its ability to enhance granulation tissue formation, collagen deposition, tissue remodeling and wound contraction. It has become evident that optimizing the topical application of curcumin through altering its formulation is essential to ensure the maximum therapeutical effects of curcumin on skin wounds.
姜黄（Curcuma longa）是一种广受欢迎的印度香料，几个世纪以来一直被用于草药中，用于治疗各种疾病，如风湿病、糖尿病溃疡、厌食症、咳嗽和鼻窦炎。姜黄素（二阿魏酰甲烷）是姜黄中主要的姜黄素类化合物，赋予其黄色。研究表明，姜黄素具有显著的抗炎、抗氧化、抗癌、抗诱变、抗凝血和抗感染作用。姜黄素还具有显著的伤口愈合特性。它作用于自然伤口愈合过程的各个阶段以加速愈合。本综述总结并讨论了最近发表的关于姜黄素对皮肤伤口愈合影响的论文。综述中突出的研究提供了证据，证明姜黄素能够降低机体对皮肤伤口的自然反应，如炎症和氧化反应。最近关于姜黄素伤口愈合特性的文献也为其增强肉芽组织形成、胶原蛋白沉积、组织重塑和伤口收缩的能力提供了证据。显然，通过改变配方优化姜黄素的局部应用对于确保姜黄素对皮肤伤口的最大治疗效果至关重要。
