Susuki Keiichiro, Rasband Matthew N
Department of Neuroscience, Baylor College of Medicine, One Baylor Plaza, Houston TX 77030, USA.
Curr Opin Cell Biol. 2008 Dec;20(6):616-23. doi: 10.1016/j.ceb.2008.09.007. Epub 2008 Nov 1.
Action potential propagation along myelinated nerve fibers requires high-density protein complexes that include voltage-gated Na(+) channels at the nodes of Ranvier. Several complementary mechanisms may be involved in node assembly including: (1) interaction of nodal cell adhesion molecules with the extracellular matrix; (2) restriction of membrane protein mobility by paranodal junctions; and (3) stabilization of ion channel clusters by axonal cytoskeletal scaffolds. In the peripheral nervous system, a secreted glial protein at the nodal extracellular matrix interacts with axonal cell adhesion molecules to initiate node formation. In the central nervous system, both glial soluble factors and paranodal axoglial junctions may function in a complementary manner to contribute to node formation.
动作电位沿有髓神经纤维的传播需要高密度的蛋白质复合物，其中包括位于郎飞结处的电压门控性钠通道。节点组装可能涉及几种互补机制，包括：（1）节点细胞粘附分子与细胞外基质的相互作用；（2）旁结连接对膜蛋白流动性的限制；（3）轴突细胞骨架支架对离子通道簇的稳定作用。在周围神经系统中，节点细胞外基质处一种分泌性胶质蛋白与轴突细胞粘附分子相互作用以启动节点形成。在中枢神经系统中，胶质可溶性因子和旁结轴突-胶质连接可能以互补方式发挥作用，促进节点形成。
