郎飞结：分子组装与维持
The Nodes of Ranvier: Molecular Assembly and Maintenance.
作者信息
Rasband Matthew N, Peles Elior
机构信息
Department of Neuroscience, Baylor College of Medicine, Houston, Texas 77030.
Department of Molecular Cell Biology, The Weizmann Institute of Science, Rehovot 76100, Israel.
出版信息
Cold Spring Harb Perspect Biol. 2015 Sep 9;8(3):a020495. doi: 10.1101/cshperspect.a020495.
Abstract
Action potential (AP) propagation in myelinated nerves requires clustered voltage gated sodium and potassium channels. These channels must be specifically localized to nodes of Ranvier where the AP is regenerated. Several mechanisms have evolved to facilitate and ensure the correct assembly and stabilization of these essential axonal domains. This review highlights the current understanding of the axon intrinsic and glial extrinsic mechanisms that control the formation and maintenance of the nodes of Ranvier in both the peripheral nervous system (PNS) and central nervous system (CNS).
摘要
动作电位（AP）在有髓神经中的传播需要聚集的电压门控钠通道和钾通道。这些通道必须特异性地定位于郎飞结，动作电位在此处再生。已经进化出几种机制来促进并确保这些重要轴突区域的正确组装和稳定。本综述重点介绍了目前对轴突内在机制和神经胶质外在机制的理解，这些机制控制着周围神经系统（PNS）和中枢神经系统（CNS）中郎飞结的形成和维持。
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