聚（甲基丙烯酸羟乙酯）-胶原蛋白植入物的结构改变

Structural alterations of p(HEMA)--collagen implants.

作者信息

Stol M, Cífková I, Tyrácková V, Adam M

机构信息

Research Institute for Rheumatic Diseases, Prague, Czechoslovakia.

出版信息

Biomaterials. 1991 Jul;12(5):454-60. doi: 10.1016/0142-9612(91)90142-w.

DOI:10.1016/0142-9612(91)90142-w

PMID:1892980

Abstract

Samples of linear (additionally crosslinked) p(HEMA) with different amounts of fibrillar collagen were implanted into the popliteal region of rats. After 3 month, the implanted materials were harvested and examined by SEM. The implants underwent marked structural or morphological changes. While the fibrillar collagen was readily resorbed by invading cells, the synthetic constituent persisted to biodegradation. The p(HEMA) residues were shaped into spherical particles, approx. 1-15 microns in diameter. The possible fate of these microparticles in the host organism is discussed.

摘要

将含有不同量纤维状胶原蛋白的线性（额外交联）聚甲基丙烯酸羟乙酯（p(HEMA)）样本植入大鼠的腘窝区域。3个月后，取出植入材料并通过扫描电子显微镜（SEM）进行检查。植入物发生了显著的结构或形态变化。虽然纤维状胶原蛋白很容易被侵入细胞吸收，但合成成分持续发生生物降解。聚甲基丙烯酸羟乙酯残留物形成了直径约为1 - 15微米的球形颗粒。讨论了这些微粒在宿主体内可能的转归。