Thanoo B C, Sunny M C, Jayakrishnan A
Polymer Chemistry Division, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Trivandrum, India.
Biomaterials. 1991 Jul;12(5):525-8. doi: 10.1016/0142-9612(91)90154-3.
Polyurethane microspheres having diameters in the range 150-1500 microns were prepared by condensation polymerization of toluene diisocyanate (TDI) with poly(tetramethylene glycol) (PTMG) of average mol wt 990 in an aqueous dispersion medium containing dioctyl sulphosuccinate (DOS) as the suspension stabilizer and 1,4-diazabicyclo[2.2.2]octane (DABCO) as the catalyst for polymerization. Incorporation of tantalum powder in the polymerizing phase led to the formation of Ta-loaded microspheres with good radiopacity. Microspheres were surface-modified by grafting methacrylic acid (MA) on to them using gamma-radiation from a Co60 source. Conversion of the grafted MA into its sodium salt imparted hydrophilicity and slipperiness to the microspheres enabling them to pass through Teflon catheters without obstructing the catheter lumen. These microspheres may find application as radiopaque embolization agents.
通过甲苯二异氰酸酯（TDI）与平均分子量为990的聚四亚甲基二醇（PTMG）在含有二辛基磺基琥珀酸酯（DOS）作为悬浮稳定剂和1,4 - 二氮杂双环[2.2.2]辛烷（DABCO）作为聚合催化剂的水性分散介质中进行缩聚反应，制备了直径在150 - 1500微米范围内的聚氨酯微球。在聚合相中加入钽粉导致形成具有良好放射性不透明度的载钽微球。使用来自Co60源的γ射线将甲基丙烯酸（MA）接枝到微球上，对微球进行表面改性。将接枝的MA转化为其钠盐赋予微球亲水性和光滑性，使其能够通过聚四氟乙烯导管而不阻塞导管腔。这些微球可作为放射性不透明栓塞剂应用。
