Hudson Susan B A, Coddington Charles C, Walker David L, Fredrickson Jolene R, Morbeck Dean E
Division of Reproductive Endocrinology and Infertility, Mayo Clinic, Rochester, Minnesota 55905, USA.
Fertil Steril. 2009 Mar;91(3):930.e17-8. doi: 10.1016/j.fertnstert.2008.08.116. Epub 2008 Oct 18.
To describe a unique case of recurrent aneuploidy and the use of preimplantation genetic screening (PGS).
Case report.
Midwest academic medical center.
PATIENT(S): A 36-year-old woman with two trisomy 21 offspring.
INTERVENTION(S): Preimplantation genetic screening.
MAIN OUTCOME MEASURE(S): Karyotype of embryos, liveborn eukaryotic infant.
RESULT(S): Preimplantation genetic screening was performed on three cryopreserved embryos, followed by a two-embryo transfer yielding a eukaryotic infant.
CONCLUSION(S): Preimplantation genetic screening may prove to be useful as a diagnostic tool to help ensure a euploid pregnancy when termination is not a viable option for a couple.
描述一例复发性非整倍体的独特病例以及植入前基因筛查（PGS）的应用。
病例报告。
中西部学术医疗中心。
一名36岁女性，有两个21三体综合征后代。
植入前基因筛查。
胚胎核型、活产真核婴儿。
对三个冷冻胚胎进行了植入前基因筛查，随后进行双胚胎移植，产下一名真核婴儿。
当终止妊娠对夫妇来说不是可行选择时，植入前基因筛查可能被证明是一种有用的诊断工具，有助于确保整倍体妊娠。
