Saresella Marina, Marventano Ivana, Guerini Franca Rosa, Zanzottera Milena, Delbue Serena, Marchioni Enrico, Maserati Renato, Longhi Renato, Ferrante Pasquale, Clerici Mario
Laboratory of Molecular Medicine and Biotechnology, Don C. Gnocchi Foundation ONLUS, IRCCS S. Maria Nascente, Via Capecelatro 66, 20148, Milan, Italy.
Clin Immunol. 2008 Dec;129(3):509-17. doi: 10.1016/j.clim.2008.08.010. Epub 2008 Oct 17.
A dynamic equilibrium between proliferation and programmed cell death (PCD) of auto-reactive T lymphocytes plays a pivotal role in the prevention of autoimmune diseases. We analyzed T lymphocytes myelin basic protein (MBP)-specific PCD and proliferation in demyelinating diseases. Results showed that MBP-specific PCD was significantly decreased in CD4+ and CD8+ T lymphocytes of progressive multifocal leukoencephalopathy (PML), not determined leukoencephalopathy (NDLE), and acute MS (AMS) patients compared to patients with stable MS (SMS) and healthy controls. MBP-specific proliferation/PCD rates were high in CD4+ T lymphocytes of PML, NDLE, and AMS patients, and in CD8+ T cells of PML and AMS individuals alone. Alterations of the balance between MBP-specific proliferation and PCD are present in demyelinating diseases and could play a major role in the pathogenesis of these diseases.
自身反应性T淋巴细胞增殖与程序性细胞死亡（PCD）之间的动态平衡在预防自身免疫性疾病中起关键作用。我们分析了脱髓鞘疾病中T淋巴细胞髓鞘碱性蛋白（MBP）特异性PCD和增殖情况。结果显示，与稳定型MS（SMS）患者和健康对照相比，进行性多灶性白质脑病（PML）、未定型白质脑病（NDLE）和急性MS（AMS）患者的CD4+和CD8+ T淋巴细胞中MBP特异性PCD显著降低。PML、NDLE和AMS患者的CD4+ T淋巴细胞以及仅PML和AMS个体的CD8+ T细胞中，MBP特异性增殖/PCD率较高。脱髓鞘疾病中存在MBP特异性增殖与PCD之间平衡的改变，这可能在这些疾病的发病机制中起主要作用。
