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多发性硬化症中的 B 淋巴细胞：Bregs 和表达 BTLA/CD272 的-CD19+ 淋巴细胞调节疾病严重程度。

B Lymphocytes in Multiple Sclerosis: Bregs and BTLA/CD272 Expressing-CD19+ Lymphocytes Modulate Disease Severity.

机构信息

Don C. Gnocchi Foundation, IRCCS, Piazza Morandi, 3, 20121 Milan, Italy.

Institute of chemistry of molecular recognition, National Research Council, Milan, Italy.

出版信息

Sci Rep. 2016 Jul 14;6:29699. doi: 10.1038/srep29699.

DOI:10.1038/srep29699
PMID:27412504
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4944189/
Abstract

B lymphocytes contribute to the pathogenesis of Multiple Sclerosis (MS) by secreting antibodies and producing cytokines. This latter function was analyzed in myelin olygodendrocyte protein (MOG)-stimulated CD19+ B lymphocytes of 71 MS patients with different disease phenotypes and 40 age-and sex-matched healthy controls (HC). Results showed that: 1) CD19+/TNFα+, CD19+/IL-12+ and CD19+/IFNγ+ lymphocytes are significantly increased in primary progressive (PP) compared to secondary progressive (SP), relapsing-remitting (RR), benign (BE) MS and HC; 2) CD19+/IL-6+ lymphocytes are significantly increased in PP, SP and RR compared to BEMS and HC; and 3) CD19+/IL-13+, CD19+/IL-10+, and CD19+/IL-10+/TGFβ+ (Bregs) B lymphocytes are reduced overall in MS patients compared to HC. B cells expressing BTLA, a receptor whose binding to HVEM inhibits TcR-initiated cytokine production, as well as CD19+/BTLA+/IL-10+ cells were also significantly overall reduced in MS patients compared to HC. Analyses performed in RRMS showed that fingolimod-induced disease remission is associated with a significant increase in Bregs, CD19+/BTLA+, and CD19+/BTLA+/IL-10+ B lymphocytes. B lymphocytes participate to the pathogenesis of MS via the secretion of functionally-diverse cytokines that might play a role in determining disease phenotypes. The impairment of Bregs and CD19+/BTLA+ cells, in particular, could play an important pathogenic role in MS.

摘要

B 淋巴细胞通过分泌抗体和产生细胞因子参与多发性硬化症 (MS) 的发病机制。在我的研究中，分析了 71 名具有不同疾病表型的 MS 患者和 40 名年龄和性别匹配的健康对照者 (HC) 的髓鞘少突胶质细胞蛋白 (MOG) 刺激的 CD19+B 淋巴细胞中的这种后一功能。结果表明：1）与继发性进展型 (SP)、复发缓解型 (RR)、良性 MS 和 HC 相比，原发性进展型 (PP) 中 CD19+/TNFα+、CD19+/IL-12+和 CD19+/IFNγ+淋巴细胞明显增加；2）与 BEMS 和 HC 相比，PP、SP 和 RR 中 CD19+/IL-6+淋巴细胞明显增加；3）与 HC 相比，MS 患者的 CD19+/IL-13+、CD19+/IL-10+和 CD19+/IL-10+/TGFβ+（Bregs）B 淋巴细胞总体减少。与 HC 相比，表达 BTLA 的 B 细胞（其与 HVEM 的结合抑制 TCR 起始的细胞因子产生）以及 CD19+/BTLA+/IL-10+B 细胞也明显减少。在 RRMS 中的分析表明，芬戈莫德诱导的疾病缓解与 Bregs、CD19+/BTLA+和 CD19+/BTLA+/IL-10+B 淋巴细胞的显著增加有关。B 淋巴细胞通过分泌功能多样的细胞因子参与 MS 的发病机制，这些细胞因子可能在确定疾病表型方面发挥作用。特别是 Bregs 和 CD19+/BTLA+细胞的损伤可能在 MS 中发挥重要的致病作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2e91/4944189/5607dc11c9f7/srep29699-f7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2e91/4944189/4abfb6402959/srep29699-f1.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2e91/4944189/3e9c939f0ecc/srep29699-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2e91/4944189/05b8f45b140e/srep29699-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2e91/4944189/847f0bcb6653/srep29699-f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2e91/4944189/6a88b806332e/srep29699-f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2e91/4944189/5607dc11c9f7/srep29699-f7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2e91/4944189/4abfb6402959/srep29699-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2e91/4944189/8f56122211b1/srep29699-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2e91/4944189/3e9c939f0ecc/srep29699-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2e91/4944189/05b8f45b140e/srep29699-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2e91/4944189/847f0bcb6653/srep29699-f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2e91/4944189/6a88b806332e/srep29699-f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2e91/4944189/5607dc11c9f7/srep29699-f7.jpg

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2
Structural and functional features of central nervous system lymphatic vessels.中枢神经系统淋巴管的结构和功能特征。
Nature. 2015 Jul 16;523(7560):337-41. doi: 10.1038/nature14432. Epub 2015 Jun 1.
3
Regulatory B cells: origin, phenotype, and function.调节性 B 细胞：起源、表型和功能。
辅酶Q10摄入对体外受精女性候选者代谢谱的影响：一项随机试验。
Ann Med Surg (Lond). 2024 Apr 26;86(6):3378-3384. doi: 10.1097/MS9.0000000000001732. eCollection 2024 Jun.
4
Single-Cell Sequencing Combined with Transcriptome Sequencing Constructs a Predictive Model of Key Genes in Multiple Sclerosis and Explores Molecular Mechanisms Related to Cellular Communication.单细胞测序联合转录组测序构建多发性硬化关键基因预测模型并探索细胞通讯相关分子机制
J Inflamm Res. 2024 Jan 9;17:191-210. doi: 10.2147/JIR.S442684. eCollection 2024.
5
Autoimmunity and Carcinogenesis: Their Relationship under the Umbrella of Autophagy.自身免疫与癌症发生：自噬框架下它们的关系
Biomedicines. 2023 Apr 8;11(4):1130. doi: 10.3390/biomedicines11041130.
6
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Cells. 2023 Jan 29;12(3):439. doi: 10.3390/cells12030439.
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Regulatory Cells in Multiple Sclerosis: From Blood to Brain.多发性硬化症中的调节性细胞：从血液到大脑
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5
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Semin Immunopathol. 2014 May;36(3):289-99. doi: 10.1007/s00281-014-0427-7. Epub 2014 Apr 29.
9
Suppressed pro-inflammatory properties of circulating B cells in patients with multiple sclerosis treated with fingolimod, based on altered proportions of B-cell subpopulations.基于 B 细胞亚群比例改变，多发性硬化症患者接受芬戈莫德治疗后循环 B 细胞抗炎特性受抑。
Clin Immunol. 2014 Apr;151(2):127-35. doi: 10.1016/j.clim.2014.02.001. Epub 2014 Feb 14.
10
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