Nemesure Barbara, Wu Suh-Yuh, Hennis Anselm, Leske M Cristina
Department of Preventive Medicine, Stony Brook University School of Medicine, Stony Brook, New York 11794-8036, USA.
Ophthalmology. 2008 Dec;115(12):2153-8. doi: 10.1016/j.ophtha.2008.08.003. Epub 2008 Oct 18.
To present 9-year incidence data and associated risk factors for pterygium among black participants in the Barbados Eye Studies.
Population-based incidence study.
A total of 1888 black participants, aged 40 to 84 years, who were free of pterygium at baseline and received an ophthalmologic study examination at the 9-year follow-up.
Age and sex-specific 9-year incidence of pterygium is presented. Risk factors were initially identified using Mantel-Haenszel analyses, and significant factors (P<0.10) were subsequently included in multivariate logistic regression models. Odds ratios (OR) and 95% confidence intervals (CI) are provided.
Development of pterygium, defined as the presence of a raised fleshy growth that crosses the limbus and encroaches onto the clear cornea.
The 9-year incidence of pterygium was 11.6% (95% CI, 10.1-13.1), with no clear pattern with increasing age and no statistically significant differences between genders. Multivariate logistic regression analyses indicated that having a lifetime outdoor job location was positively associated with the development of pterygium (OR = 1.51; 95% CI, 1.05-2.16), whereas darker skin color (OR = 0.67; 95% CI, 0.46-0.97) and use of any prescription lenses (OR = 0.58; 95% CI, 0.42-0.81) were found to be protective factors.
The incidence of pterygium was high in this population, for an average of 1.3% per year. Working outdoors increased the risk 1.5-fold, whereas having a darker skin complexion and using eyewear for either reading or distance substantially decreased the risk of developing pterygium. These data suggest that absorption of ultraviolet light plays a role in this condition and that preventive strategies are needed to decrease the burden of pterygium development in this and other populations.
FINANCIAL DISCLOSURE(S): The authors have no proprietary or commercial interest in any materials discussed in this article.
呈现巴巴多斯眼研究中黑人参与者翼状胬肉的9年发病率数据及相关危险因素。
基于人群的发病率研究。
共有1888名年龄在40至84岁之间的黑人参与者，他们在基线时无翼状胬肉，并在9年随访时接受了眼科检查。
呈现按年龄和性别划分的翼状胬肉9年发病率。危险因素最初通过Mantel-Haenszel分析确定，随后将显著因素（P<0.10）纳入多变量逻辑回归模型。提供比值比（OR）和95%置信区间（CI）。
翼状胬肉的发生，定义为出现跨越角膜缘并侵入透明角膜的隆起的肉质生长物。
翼状胬肉的9年发病率为11.6%（95%CI，10.1 - 13.1），未随年龄增长呈现明显模式，且性别间无统计学显著差异。多变量逻辑回归分析表明，从事终身户外工作与翼状胬肉的发生呈正相关（OR = 1.51；95%CI，1.05 - 2.16），而肤色较深（OR = 0.67；95%CI，0.46 - 0.97）和使用任何处方眼镜（OR = 0.58；95%CI，0.42 - 0.81）被发现是保护因素。
该人群中翼状胬肉的发病率较高，平均每年为1.3%。户外工作使风险增加1.5倍，而肤色较深以及使用阅读或远视眼镜则大幅降低了患翼状胬肉的风险。这些数据表明紫外线吸收在这种情况中起作用，并且需要采取预防策略来减轻该人群及其他人群中翼状胬肉发生的负担。
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