Li Lan, Zhong Hua, Tian Ermiao, Yu Minbin, Yuan Yuansheng, Yang Wenyan, Wei Tao, Cha Xueping, Li Xun, Li Juanjuan, Su Xiaodan, Pan Chen-Wei
*Department of Ophthalmology, the First People's Hospital of Kunming City, Kunming, China; †Department of Ophthalmology, the First Affiliated Hospital of Kunming Medical University, Kunming, China; ‡Kunming Medical University, Kunming, China; §State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China; and ¶School of Public Health, Medical College of Soochow University, Suzhou, China.
Cornea. 2015 Dec;34(12):1564-8. doi: 10.1097/ICO.0000000000000637.
To determine the 5-year cumulative incidence of pterygium and its associated predictors in the Bai Chinese population in a rural community.
This population-based study included 2133 subjects aged 50 years or older in 2010 and was repeated in 2015 with 1520 subjects (71.3%) participating in the follow-up examination. Participants with pterygium in either eye in 2010 were excluded from the analysis related to incidence. Anterior segment examination was performed without pupil dilation using a slit lamp, and pterygium was defined as a raised fleshy triangular fibrovascular tissue growth of the conjunctiva encroaching onto the clear cornea.
The 5-year cumulative incidence of pterygium was 6.8% [95% confidence interval (CI), 5.2-8.4] and was significantly higher in women compared with men (8.8% vs. 3.8%; P = 0.003). The age-specific incidence was 7.7%, 6.5%, and 5.6% in those aged 50-59, 60-69, 70 years, or older at the baseline, respectively. Outdoor occupation was the only predictor, which remained to be significantly associated with a higher incidence of pterygium in multivariate analysis (odds ratio = 2.52, 95% CI, 1.27-4.95). The predictive effect of outdoor occupation on incident pterygium was moderate with an area under the curve in the receiver operating characteristic analysis of 0.59 (95% CI, 0.53-0.66).
The incidence of pterygium in this rural cohort was higher compared to a previous report in Chinese in urban areas. The findings are important for health policy makers to project future burden of pterygium and make proper decisions on health resource allocation.
确定农村社区白族人群中翼状胬肉的5年累积发病率及其相关预测因素。
这项基于人群的研究纳入了2010年2133名年龄在50岁及以上的受试者，并于2015年进行重复研究，有1520名受试者（71.3%）参与了随访检查。2010年任何一只眼睛患有翼状胬肉的参与者被排除在发病率相关分析之外。使用裂隙灯在未散瞳的情况下进行眼前节检查，翼状胬肉定义为结膜上隆起的肉质三角形纤维血管组织生长并侵入透明角膜。
翼状胬肉的5年累积发病率为6.8%[95%置信区间（CI），5.2 - 8.4]，女性显著高于男性（8.8%对3.8%；P = 0.003）。基线时年龄在50 - 59岁、60 - 69岁、70岁及以上人群的年龄别发病率分别为7.7%、6.5%和5.6%。户外职业是唯一的预测因素，在多变量分析中仍与翼状胬肉的较高发病率显著相关（比值比 = 2.52，95% CI，1.27 - 4.95）。户外职业对翼状胬肉发病的预测作用中等，在接受者操作特征分析中的曲线下面积为0.59（95% CI，0.53 - 0.66）。
与之前中国城市地区的一份报告相比，该农村队列中翼状胬肉的发病率更高。这些发现对于卫生政策制定者预测未来翼状胬肉的负担并就卫生资源分配做出适当决策具有重要意义。
