Koletsa Triantafyllia, Karayannopoulou Georgia, Dereklis Dimitrios, Vasileiadis Ippokratis, Papadimitriou Constantine S, Hytiroglou Prodromos
Department of Pathology, Aristotle University Medical School, 540 06 Thessaloniki, Greece.
Pathol Res Pract. 2009;205(2):125-30. doi: 10.1016/j.prp.2008.06.004. Epub 2008 Oct 18.
Mesectodermal leiomyoma of the ciliary body is a rare benign tumor with double (muscular and neural) differentiation. This neoplasm is considered to originate from the ciliary body smooth muscle, a neural crest derivative. We report a case of mesectodermal leiomyoma of the right eye occurring in a 53-year-old woman, who presented with significant decrease of visual acuity. A malignant melanoma was highly suspected on clinical evaluation, and the globe was enucleated. The tumor measured 1.2cm in greatest dimension, and consisted of spindle and ovoid cells with abundant fibrillary cytoplasmic processes. Immunohistochemical stains revealed positivity for smooth muscle actin, caldesmon, neuron-specific enolase, and CD56 antigen. A review of the 23 cases thus far reported in the literature shows a striking predilection for women, as well as significant difficulties in differentiating this tumor from malignant melanoma on clinical grounds.
睫状体中胚层平滑肌瘤是一种罕见的具有双重（肌肉和神经）分化的良性肿瘤。该肿瘤被认为起源于睫状体平滑肌，而睫状体平滑肌是神经嵴的衍生物。我们报告了一例发生在一名53岁女性右眼的中胚层平滑肌瘤，该患者出现视力显著下降。临床评估高度怀疑为恶性黑色素瘤，遂行眼球摘除术。肿瘤最大直径为1.2cm，由具有丰富纤维状胞质突起的梭形和卵圆形细胞组成。免疫组织化学染色显示平滑肌肌动蛋白、钙调蛋白、神经元特异性烯醇化酶和CD56抗原呈阳性。对文献中迄今报道的23例病例的回顾显示，该肿瘤明显好发于女性，并且在临床上很难将其与恶性黑色素瘤区分开来。
