Kamil Z S, Tong L C B, Habeeb A Al, Ghazarian D
Department of Laboratory Medicine and Pathobiology, University of Toronto and University Health Network, Toronto, Ontario, Canada.
J Clin Pathol. 2009 Feb;62(2):120-7. doi: 10.1136/jcp.2008.060863. Epub 2008 Oct 17.
Melanoma comprises a wide range of cytological and architectural features histopathologically and hence can mimic many benign and malignant lesions of epithelial, mesenchymal and hematopoietic cell lines of differentiation. Therefore, analysis and close clinical, histological, histochemical and immunohistochemical correlation is vital in distinguishing challenging melanoma cases from their mimics. In this review, the different features of the benign, pre-malignant and malignant intraepidermal non-melanocytic tumours and tumour-like lesions that can closely mimic intraepidermal melanoma (melanoma in situ) are emphasised.
黑色素瘤在组织病理学上具有广泛的细胞学和结构特征，因此可模仿上皮、间充质和造血细胞系分化的许多良性和恶性病变。所以，分析并密切结合临床、组织学、组织化学和免疫组织化学进行相关性研究，对于区分具有挑战性的黑色素瘤病例与其模仿病变至关重要。在本综述中，重点强调了可紧密模仿表皮内黑色素瘤（原位黑色素瘤）的良性、癌前和恶性表皮内非黑素细胞肿瘤及肿瘤样病变的不同特征。
